DYSF

Gene Symbol	DYSF
Entrez Gene	8291
Alt Symbol	FER1L1, LGMD2B, MMD1
Species	Human
Gene Type	protein-coding
Description	dysferlin
Other Description	dystrophy-associated fer-1-like 1|fer-1-like family member 1|fer-1-like protein 1|limb girdle muscular dystrophy 2B (autosomal recessive)
Swissprots	B1PZ81 B1PZ80 B1PZ72 Q9UEN7 B1PZ79 B1PZ78 B1PZ77 Q53TD2 A0FK00 B1PZ70 Q53QY3 B3KQB9 O75923 B1PZ75 Q09EX5 B1PZ71 Q8TEL8 Q0H395 O75696 B1PZ73 B1PZ76 B1PZ74
Accessions	AAY14954 AAY24199 ABI75150 ABK20181 ADQ57464 CAA07800 CAD92859 EAW99763 EAW99764 EAW99765 O75923 AF075575 AAC63519 AI128455 AI192657 AI739271 AK074104 BAB84930 AK074442 BAB85086 AK074649 BAG51981 AK295004 BAH11947 AK303364 BAH13950 AK310739 BC038246 BC171803 BC172229 AAI72229 DB292971 DQ267935 ABB89736 EU515155 ACB12752 EU515156 ACB12753 EU515157 ACB12754 EU515158 ACB12755 EU515159 ACB12756 EU515160 ACB12757 EU515161 ACB12758 EU515162 ACB12759 EU515163 ACB12760 EU515164 ACB12761 EU515165 ACB12762 EU515166 ACB12763 XM_005264584 XP_005264641 XM_005264585 XP_005264642 NM_001130455 NP_001123927 NM_001130976 NP_001124448 NM_001130977 NP_001124449 NM_001130978 NP_001124450 NM_001130979 NP_001124451 NM_001130980 NP_001124452 NM_001130981 NP_001124453 NM_001130982 NP_001124454 NM_001130983 NP_001124455 NM_001130984 NP_001124456 NM_001130985 NP_001124457 NM_001130986 NP_001124458 NM_001130987 NP_001124459 NM_003494 NP_003485
Function	Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasmic vesicle membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cell membrane. Note=Colocalizes, during muscle differentiation, with BIN1 in the T-tubule system of myotubules and at the site of contact between two myotubes or a myoblast and a myotube. Wounding of myotubes led to its focal enrichment to the site of injury and to its relocalization in a Ca(2+)-dependent manner toward the plasma membrane. Colocalizes with AHNAK, AHNAK2 and PARVB at the sarcolemma of skeletal muscle. Detected on the apical plasma membrane of the syncytiotrophoblast. Reaches the plasmma membrane through a caveolin-independent mechanism. Retained by caveolin at the plasmma membrane (By similarity). Colocalizes, during muscle differentiation, with CACNA1S in the T-tubule system of myotubules (By similarity). Accumulates and colocalizes with fusion vesicles at the sarcolemma disruption sites (By similarity). {ECO:0
Tissue Specificity	Expressed in skeletal muscle, myoblast, myotube and in the syncytiotrophoblast (STB) of the placenta (at protein level). Ubiquitous. Highly expressed in skeletal muscle. Also found in heart, brain, spleen, intestine, placenta and at lower levels in liver, lung, kidney and pancreas. {ECO:0000269|PubMed:10196375, ECO:0000269|PubMed:11532985, ECO:0000269|PubMed:11959863, ECO:0000269|PubMed:15318348, ECO:0000269|PubMed:16896923, ECO:0000269|PubMed:17185750, ECO:0000269|PubMed:17363620, ECO:0000269|PubMed:17554076, ECO:0000269|PubMed:24239457}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human Dysferlin ELISA Kit (Cell-Based ELISA) - LS-F1949 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 31.25-2000 pg/ml

Human Dysferlin ELISA Kit (Sandwich ELISA) - LS-F7356 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 12.5 pg/ml Range 31.25-2000 pg/ml

Human Dysferlin ELISA Kit - abx151362 from Abbexa Category ELISA Kit Sensitivity 0.112 ng/ml Range 0.313 ng/ml - 20 ng/ml

Dysferlin (DYSF), Human, ELISA Kit - CSB-EL007314HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Dysferlin (DYSF), Human, ELISA Kit - SEC445Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.141ng/mL Range 0.312-20ng/mL

Dysferlin Colorimetric Cell-Based ELISA Kit - CB5213 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Dysferlin, ELISA Kit - MBS102944 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Dysferlin, ELISA Kit - MBS105523 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Dysferlin, ELISA Kit - MBS058737 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Dysferlin, ELISA Kit - MBS108222 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Dysferlin, ELISA Kit - MBS070847 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Dysferlin, ELISA Kit - MBS085699 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Dysferlin, ELISA Kit - MBS057834 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Dysferlin (DYSF), ELISA Kit - MBS2024255 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 12.5pg/mL. Range 31.25-2000pg/mL

dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) , ELISA Kit - MBS915564 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human DYSF is typically less than 7.81 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 31.25 pg/ml -2000 pg/ml.

ELISA Kit for Dysferlin (DYSF) - SEC445Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 12.5pg/mL. Range 31.25-2000pg/mL The standard curve concentrations used for the ELISA’s were 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL

Human Dysferlin(DYSF) ELISA kit - CSB-EL007314HU from Cusabio Category ELISA Kit Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

ELISA Kit for Dysferlin (DYSF) - SEC445Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 12.5pg/mL. Range 31.25-2000pg/mL The standard curve concentrations used for the ELISA's were 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL

Human Dysferlin (DYSF) ELISA Kit - EKU03812 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 12.5 pg/mL Range 31.25-2000 pg/mL

Dysferlin (DYSF), Human, ELISA Kit - DL-DYSF-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Dysferlin ELISA Kit - DEIA-XYA565 from Creative Diagnostics Category ELISA Kit

Human DYSF ELISA Kit - abx572548 from Abbexa Category ELISA Kit Sensitivity 0.141 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human Dysferlin(DYSF) ELISA Kit - EKC33510 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,287.50 Sizes 96 t, 5x96t, 10x96t Sensitivity 7.81 pg/ml Range 31.25 pg/ml-2000 pg/ml

Human DYSF ELISA Kit - E012561 from Biobool Category ELISA Kit Sensitivity Typically less than 12.5pg/mL.

DYSF ELISA Kit (Human) (OKCD00759) - OKCD00759 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 12.5 pg/mL Range 31.25-2,000 pg/mL

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