| Gene Symbol | KRAS |
|---|---|
| Entrez Gene | 3845 |
| Alt Symbol | C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RASK2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Kirsten rat sarcoma viral oncogene homolog |
| Other Description | GTPase KRas|K-Ras 2|K-ras p21 protein|PR310 c-K-ras oncogene|c-Ki-ras|c-Kirsten-ras protein|cellular c-Ki-ras2 proto-oncogene|oncogene KRAS2|transforming protein p21|v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog |
| Swissprots | A8K8Z5 Q96D10 P01116 P01118 B0LPF9 |
| Accessions | AAA36148 AAA36149 AAA36554 AAB59444 AAB59445 AAD13953 AAF91482 ABP96992 ABP97009 ABP97013 ABP97015 ABS10683 ABS10684 ABY87538 ADQ00188 AFF18187 AGC09594 CAA25828 CAA26593 CBK51852 CBK51925 CBV35640 CDL93479 EAW96511 EAW96512 EAW96513 EAW96514 P01116 AA812162 AF493917 AAM12631 AI539465 AK292510 BAF85199 AW117295 BC010502 BC013572 AAH13572 BC029545 BG258021 BT007153 AAP35817 CD245555 DQ890649 ABM81575 DQ893829 ABM84755 M17087 AAA36555 M35504 AAA35689 M35505 AAA35690 M54968 AAB41942 XM_006719069 XP_006719132 XM_011520653 XP_011518955 NM_004985 NP_004976 NM_033360 NP_203524 |
| Function | Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). {ECO:0000269|PubMed:22711838, ECO:0000269|PubMed:23698361, ECO:0000305}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:23698361}; Lipid-anchor {ECO:0000305|PubMed:23698361}; Cytoplasmic side {ECO:0000305|PubMed:23698361}. Cytoplasm, cytosol {ECO:0000269|PubMed:23698361}. |
| Top Pathways | Axon guidance, Tight junction, VEGF signaling pathway, Gap junction, Natural killer cell mediated cytotoxicity |