| Gene Symbol |
CHTF8
|
| Entrez Gene |
54921
|
| Alt Symbol |
CTF8, DERPC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
|
| Other Description |
chromosome transmission fidelity protein 8 homolog|decreased expression in renal and prostate cancer protein
|
| Swissprots |
Q8NDH8 A8MYX8 Q9NX73 Q8WV66 P0CG13 Q71E72 P0CG12
|
| Accessions |
CCO13708 EAW83250 P0CG12 P0CG13 AF525164 AAQ08897 AK000407 BAA91144 AL833902 CAD38758 BC018700 AAH18700 BC069059 BM820172 BP195395 BP222147 BU631276 BU739855 CB135653 CB147424 CN388626 DA076128 DA378951 DB188088 XM_011523167 XP_011521469 XM_011523168 XP_011521470 XR_933347 NM_001039690 NP_001034779 NM_001040146 NP_001035236 NR_033227 NM_001002847 NM_001040144 NM_001040145 NM_017804
|
| Function |
Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed. {ECO:0000269|PubMed:12477976}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12477976}.
|
| Tissue Specificity |
Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver, ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate tumors. No differential expression in breast cancer cells, between lobular carcinoma and normal lobules. {ECO:0000269|PubMed:12477976, ECO:0000269|PubMed:18213475}.
|
![Western Blot: CHTF8 Overexpression Lysate (Adult Normal) [NBP2-08503] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CHTF8.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/14700_CHTF8%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-08503-img0001.jpg)
![Western Blot: CHTF8 Overexpression Lysate (Adult Normal) [NBP2-09211] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CHTF8.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10709_CHTF8%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09211-img0001.jpg)