| Gene Symbol | TLE4 |
|---|---|
| Entrez Gene | 7091 |
| Alt Symbol | BCE-1, BCE1, E(spI), ESG, ESG4, GRG4, Grg-4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | transducin-like enhancer of split 4 |
| Other Description | B lymphocyte gene 1|enhancer of split groucho 4|groucho-related protein 4|transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)|transducin-like enhancer of split 4, homolog of Drosophila E(sp1)|transducin-like enhancer protein 4 |
| Swissprots | F8W6T6 Q5T1Y2 Q9BZ08 Q3ZCS1 Q9NSL3 Q6PCB3 Q9BZ07 Q04727 Q9ULF9 Q9BZ09 |
| Accessions | EAW62627 EAW62628 EAW62629 EAW62630 EAW62631 EAW62632 Q04727 AB033087 BAA86575 AF068197 AAC18942 AI279314 AI620368 AK057236 BAG51891 AK296342 BAG59027 AK302709 BAG63931 AL162059 CAB82397 BC036369 BC045650 AAH45650 BC059405 AAH59405 BC060038 BC063695 BQ006122 HQ283388 M99439 AAA61195 W68064 XM_005252177 XP_005252234 XM_006717264 XP_006717327 XM_006717268 XP_006717331 XM_011518952 XP_011517254 XM_011518953 XP_011517255 XM_011518954 XP_011517256 XM_011518955 XP_011517257 XM_011518956 XP_011517258 XM_011518957 XP_011517259 XM_011518958 XP_011517260 XM_011518959 XP_011517261 XM_011518960 XP_011517262 XM_011518961 XP_011517263 XM_011518962 XP_011517264 XM_011518963 XP_011517265 XM_011518964 XP_011517266 XM_011518965 XP_011517267 XM_011518966 XP_011517268 XM_011518967 XP_011517269 XM_011518968 XP_011517270 XM_011518969 XP_011517271 XM_011518970 XP_011517272 XM_011518971 XP_011517273 XM_011518972 XP_011517274 NM_001282748 NP_001269677 NM_001282749 NP_001269678 NM_001282753 NP_001269682 NM_001282760 NP_001269689 NM_007005 NP_008936 NR_104239 |
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. |
| Tissue Specificity | In all tissues examined, mostly in brain, and muscle. |
TLE4 CRISPR/Cas9 KO Plasmid (h) - sc-401215 from Santa Cruz Biotechnology
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TLE4 HDR Plasmid (h) - sc-401215-HDR from Santa Cruz Biotechnology
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TLE4 Double Nickase Plasmid (h) - sc-401215-NIC from Santa Cruz Biotechnology
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TLE4 Double Nickase Plasmid (h2) - sc-401215-NIC-2 from Santa Cruz Biotechnology
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TLE4 CRISPR Activation Plasmid (h) - sc-401215-ACT from Santa Cruz Biotechnology
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TLE4 CRISPR Activation Plasmid (h2) - sc-401215-ACT-2 from Santa Cruz Biotechnology
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TLE4 Lentiviral Activation Particles (h) - sc-401215-LAC from Santa Cruz Biotechnology
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TLE4 Lentiviral Activation Particles (h2) - sc-401215-LAC-2 from Santa Cruz Biotechnology
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TLE4 siRNA (h) - sc-38562 from Santa Cruz Biotechnology
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TLE4 shRNA Plasmid (h) - sc-38562-SH from Santa Cruz Biotechnology
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TLE4 shRNA (h) Lentiviral Particles - sc-38562-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU150551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21392 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21392 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09887 from Sigma-Aldrich
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TLE4 siRNA (Human) - CRH4858 from Cohesion Biosciences
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TLE4 - MBS8230319 from MyBioSource
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shRNA set against Human TLE4 (NM_007005.3) - SHH427828 from Creative biogene
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shRNA set against Human TLE4(NM_007005.3) - SHG210601 from Creative biogene
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TLE4 shRNA Plasmid (Human) - CHH4858 from Cohesion Biosciences
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TLE4 miRNA 3'UTR clone - MiUTR1H-10429 from Creative biogene
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