| Gene Symbol |
Adhfe1
|
| Entrez Gene |
362474
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
alcohol dehydrogenase, iron containing, 1
|
| Other Description |
HOT|alcohol dehydrogenase iron-containing protein 1|hydroxyacid-oxoacid transhydrogenase, mitochondrial
|
| Swissprots |
Q4QQW3
|
| Accessions |
EDM11561 EDM11562 EDM11563 EDM11564 EDM11565 Q4QQW3 BC085821 BC097945 AAH97945 XM_008763507 XP_008761729 XM_008763508 XP_008761730 XM_008763509 XP_008761731 XM_008763510 XP_008761732 NM_001025423 NP_001020594
|
| Function |
Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:3182820}.
|
| Tissue Specificity |
Expressed in kidney and liver. {ECO:0000269|PubMed:3182820}.
|