Gene Symbol | BLMH |
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Entrez Gene | 642 |
Alt Symbol | BH, BMH |
Species | Human |
Gene Type | protein-coding |
Description | bleomycin hydrolase |
Other Description | BLM hydrolase |
Swissprots | B2R796 Q9UER9 Q53F86 Q13867 |
Accessions | CAA74767 EAW51224 Q13867 AF091082 AAC72951 AI283058 AK057600 AK223403 BAD97123 AK301948 BAG63365 AK312896 BAG35743 BC003616 AAH03616 BG471412 BT007018 AAP35664 DC346179 X92106 CAA63078 NM_000386 NP_000377 |
Function | The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. {ECO:0000250}. |
Subcellular Location | Cytoplasm. |
BLM hydrolase CRISPR/Cas9 KO Plasmid (h) - sc-404411 from Santa Cruz Biotechnology
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BLM hydrolase HDR Plasmid (h) - sc-404411-HDR from Santa Cruz Biotechnology
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BLM hydrolase Double Nickase Plasmid (h) - sc-404411-NIC from Santa Cruz Biotechnology
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BLM hydrolase Double Nickase Plasmid (h2) - sc-404411-NIC-2 from Santa Cruz Biotechnology
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BLM hydrolase CRISPR Activation Plasmid (h) - sc-404411-ACT from Santa Cruz Biotechnology
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BLM hydrolase CRISPR Activation Plasmid (h2) - sc-404411-ACT-2 from Santa Cruz Biotechnology
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BLM hydrolase Lentiviral Activation Particles (h) - sc-404411-LAC from Santa Cruz Biotechnology
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BLM hydrolase Lentiviral Activation Particles (h2) - sc-404411-LAC-2 from Santa Cruz Biotechnology
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BLM hydrolase siRNA (h) - sc-72654 from Santa Cruz Biotechnology
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BLM hydrolase shRNA Plasmid (h) - sc-72654-SH from Santa Cruz Biotechnology
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BLM hydrolase shRNA (h) Lentiviral Particles - sc-72654-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU033171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1697 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1697 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06738 from Sigma-Aldrich
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BLMH siRNA (Human) - CRH0438 from Cohesion Biosciences
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BLMH/Bleomycin Hydrolase RNAi - H00000642-R01 from Novus Biologicals
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BLMH - MBS8205131 from MyBioSource
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BLM hydrolase CRISPR/Cas9 KO Plasmid (h2) - sc-404411-KO-2 from Santa Cruz Biotechnology
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BLM hydrolase HDR Plasmid (h2) - sc-404411-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human BLMH (NM_000386.3) - SHH246878 from Creative biogene
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BLMH shRNA Plasmid (Human) - CHH0438 from Cohesion Biosciences
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BLMH miRNA 3'UTR clone - MiUTR3H-04947 from Creative biogene
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