NPHP1

Gene Symbol	NPHP1
Entrez Gene	4867
Alt Symbol	JBTS4, NPH1, SLSN1
Species	Human
Gene Type	protein-coding
Description	nephronophthisis 1 (juvenile)
Other Description	juvenile nephronophthisis 1 protein|nephrocystin 1|nephrocystin-1
Swissprots	O14837 O15259
Accessions	EAW50631 EAW50632 EAW50633 EAW50634 EAW50635 EAW50636 EAW50637 O15259 AF023674 AAC51771 AI433852 AJ001815 CAA05030 AK225600 AK299011 BAG61092 AK307654 BC009789 BC032939 BC062574 AAH62574 BX571745 CAE11870 DB454094 HQ447938 ADQ32422 XM_005263675 XP_005263732 XM_005263676 XP_005263733 XM_005263677 XP_005263734 XM_005263678 XP_005263735 XM_005263679 XP_005263736 XM_006712551 XP_006712614 XM_006712552 XP_006712615 XM_011511244 XP_011509546 NM_000272 NP_000263 NM_001128178 NP_001121650 NM_001128179 NP_001121651 NM_207181 NP_997064
Function	Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development. In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity). {ECO:0000250}.
Subcellular Location	Cell junction, adherens junction {ECO:0000250}. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cell junction, tight junction. Note=Colocalizes with E-cadherin and BCAR1 at or near the cell-cell adherens junctions (By similarity). Localized to respiratory cilia axoneme. Localized to the transition zone of respiratory cilia, photoreceptor-connecting cilia and renal monocilia. In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions. {ECO:0000250}.
Tissue Specificity	Widespread expression, with highest levels in pituitary gland, spinal cord, thyroid gland, testis, skeletal muscle, lymph node and trachea. Weakly expressed in heart, kidney and pancreas. Expressed in nasal epithelial cells (at protein level). {ECO:0000269|PubMed:16308564}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Nephronophthisis full length protein - ab159011 from Abcam Category Protein Source Wheat germ Species Human

Human Nephronophthisis protein fragment - ab159012 from Abcam Category Protein Source Wheat germ Species Human

NPHP1 / Nephronophthisis Antibody Blocking Peptide - LS-E20305 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Nephronophthisis Protein - H00004867-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Nephronophthisis Protein - H00004867-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant human Nephrocystin-1 (OPCA00173) - OPCA00173 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human NPHP1 protein - orb244409 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

NPHP1 peptide - orb217687 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

NPHP1 Blocking Peptide - 33R-3334 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Nephrocystin 1 Blocking Peptide - abx063018 from Abbexa Category Peptide Species Human, Mouse, Rat

Nephrocystin 1 - H00004867-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Nephrocystin 1 - H00004867-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Nephrocystin 1 - H00004867-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Nephrocystin 1 - H00004867-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NPHP1 fusion protein - ag6696 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

NPHP1 fusion protein - ag19671 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

NPHP1 fusion protein - Ag22965 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PGEX-4T Species Human

Nephrocystin 1 Blocking Peptide - CBP1824 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Human Nephrocystin-1(NPHP1) - CSB-YP015985HU CSB-BP015985HU CSB-MP015985HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Nephrocystin-1 - CSB-EP015985HU from Cusabio Category Protein Source E.coli Species Human

Nephrocystin-1 - RPC140928 from Biomatik Category Protein Prices $299.20, $352.00, $550.00, $687.50, $997.50, $1,507.50 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Nephronophthisis Recombinant Protein Antigen - NBP2-13672PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

NPHP1 Peptide, Human - M34GP10549H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant human Nephrocystin-1 - AP70590 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Nephrocystin-1 , Recombinant Protein - MBS1235759 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $1,180.00, $1,545.00, $1,770.00, $1,770.00, $2,650.00, $3,095.00, $3,095.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

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