| Gene Symbol |
DRD4
|
| Entrez Gene |
1815
|
| Alt Symbol |
D4DR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dopamine receptor D4
|
| Other Description |
D(2C) dopamine receptor|D(4) dopamine receptor|dopamine D4 receptor|seven transmembrane helix receptor
|
| Swissprots |
Q8NGM5 B0M0J7 Q7Z7Q5 P21917
|
| Accessions |
AAB46802 AAB46803 AAL35159 AAL35160 AAL35161 AAL35162 AAL35163 AAL35164 AAL35165 AAL35166 AAL35167 AAL35168 AAL35169 AAL35170 AAL35171 AAL35172 AAL35173 AAL35174 AAL35175 AAL35176 AAL35177 AAL35178 AAL35179 AAL35180 AAL35181 AAL35182 AAL35183 AAL35184 AAL35185 AAL35186 AAL35187 AAL35188 AAL35189 AAL35190 AAL35191 AAL35192 AAL35193 AAL35194 AAL35195 AAL35196 AAL35197 AAL35198 AAL35199 AAL35200 AAL35201 AAL35202 AAL35203 AAL35204 AAL35205 AAL35206 AAL35207 AAL35208 AAL35209 AAL35210 AAL35211 AAL35212 AAL35213 AAL58637 AAN73253 AAN73255 AAN73256 AAN73257 AAN73258 AAN73259 AAN73260 AAN73261 AAN73262 AAN73263 AAN73264 AFU07590 BAC05985 BAD00718 BAD00719 BAD00720 EAX02369 P21917 BC172267 AAI72267 BM674709 EU432112 ABY87911 L12398 AAB59386 S76942 AAB33728 NM_000797 NP_000788
|
| Function |
Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:20100572}; Multi-pass membrane protein {ECO:0000269|PubMed:20100572}.
|
| Top Pathways |
Dopaminergic synapse, Neuroactive ligand-receptor interaction
|