Gene Symbol | WDR6 |
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Entrez Gene | 11180 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | WD repeat domain 6 |
Other Description | WD repeat-containing protein 6 |
Swissprots | Q3MIT1 B4DHK2 Q9NNW5 Q9UF63 |
Accessions | Q9NNW5 AF099100 AAF80244 AI636120 AK001080 BAA91497 AK022719 BAB14201 AK092079 BAG52480 AK225653 AK295145 BAG58164 AK296387 BAG59057 AK297090 BAG59605 AK304117 BAG65018 AK309913 AL133589 CAB63730 AL833910 CAD38766 BC002826 AAH02826 BC078176 AAH78176 BC101707 AAI01708 BC113467 AAI13468 BC143486 BC143488 DC389885 DC400613 XM_005264837 XP_005264894 XM_011533314 XP_011531616 XR_940365 NM_018031 NP_060501 |
Function | Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy. {ECO:0000269|PubMed:17216128, ECO:0000269|PubMed:22354037}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17216128}. Note=Colocalizes in the cytoplasm with STK11/LKB1. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10903905}. |
WDR6 CRISPR/Cas9 KO Plasmid (h) - sc-411584 from Santa Cruz Biotechnology
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WDR6 HDR Plasmid (h) - sc-411584-HDR from Santa Cruz Biotechnology
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WDR6 Double Nickase Plasmid (h) - sc-411584-NIC from Santa Cruz Biotechnology
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WDR6 Double Nickase Plasmid (h2) - sc-411584-NIC-2 from Santa Cruz Biotechnology
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WDR6 CRISPR Activation Plasmid (h) - sc-411584-ACT from Santa Cruz Biotechnology
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WDR6 CRISPR Activation Plasmid (h2) - sc-411584-ACT-2 from Santa Cruz Biotechnology
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WDR6 Lentiviral Activation Particles (h) - sc-411584-LAC from Santa Cruz Biotechnology
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WDR6 Lentiviral Activation Particles (h2) - sc-411584-LAC-2 from Santa Cruz Biotechnology
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WDR6 siRNA (h) - sc-78080 from Santa Cruz Biotechnology
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WDR6 shRNA Plasmid (h) - sc-78080-SH from Santa Cruz Biotechnology
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WDR6 shRNA (h) Lentiviral Particles - sc-78080-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU065441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22841 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05637 from Sigma-Aldrich
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WDR6 siRNA (Human) - CRH7660 from Cohesion Biosciences
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WDR6 RNAi - H00011180-R01 from Novus Biologicals
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WDR6 - MBS8234909 from MyBioSource
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shRNA set against Human WDR6 (NM_018031.3) - SHH446340 from Creative biogene
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WDR6 shRNA Plasmid (Human) - CHH7660 from Cohesion Biosciences
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WDR6 miRNA 3'UTR clone - MiUTR3H-08156 from Creative biogene
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