| Gene Symbol | IL6 |
|---|---|
| Entrez Gene | 3569 |
| Alt Symbol | BSF2, HGF, HSF, IFNB2, IL-6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 6 |
| Other Description | B-cell differentiation factor|B-cell stimulatory factor 2|BSF-2|CDF|CTL differentiation factor|IFN-beta-2|hybridoma growth factor|interferon beta-2|interferon, beta 2|interleukin BSF-2|interleukin-6 |
| Swissprots | P05231 Q9UCU2 Q9UCU3 Q9UCU4 |
| Accessions | AAC05673 AAK48987 AAN75009 AAS07539 AFF18412 CAA27990 CAA68278 CAL23031 CCA63961 EAL24265 EAW93756 EAW93757 EAW93758 P05231 A09363 CAA00839 AA721478 AK298013 BAG60317 AK298077 BAG60365 AK301141 BAG62733 BC015511 AAH15511 BT019748 AAV38553 BT019749 AAV38554 CR450296 CAG29292 DQ891463 ABM82389 DQ894639 ABM85565 M14584 AAA52728 M18403 AAA52729 M29150 AAA59154 M54894 AAC41704 S56892 AAD13886 X04403 CAA27991 X04430 CAA28026 X04602 CAA28268 XM_005249745 XP_005249802 XM_011515390 XP_011513692 XM_011515391 XP_011513693 NM_000600 NP_000591 |
| Function | Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. |
| Subcellular Location | Secreted. |
| Top Pathways | Non-alcoholic fatty liver disease (NAFLD), Legionellosis, TNF signaling pathway, Herpes simplex infection, PI3K-Akt signaling pathway |