IL6

Gene Symbol IL6
Entrez Gene 3569
Alt Symbol BSF2, HGF, HSF, IFNB2, IL-6
Species Human
Gene Type protein-coding
Description interleukin 6
Other Description B-cell differentiation factor|B-cell stimulatory factor 2|BSF-2|CDF|CTL differentiation factor|IFN-beta-2|hybridoma growth factor|interferon beta-2|interferon, beta 2|interleukin BSF-2|interleukin-6
Swissprots P05231 Q9UCU2 Q9UCU3 Q9UCU4
Accessions AAC05673 AAK48987 AAN75009 AAS07539 AFF18412 CAA27990 CAA68278 CAL23031 CCA63961 EAL24265 EAW93756 EAW93757 EAW93758 P05231 A09363 CAA00839 AA721478 AK298013 BAG60317 AK298077 BAG60365 AK301141 BAG62733 BC015511 AAH15511 BT019748 AAV38553 BT019749 AAV38554 CR450296 CAG29292 DQ891463 ABM82389 DQ894639 ABM85565 M14584 AAA52728 M18403 AAA52729 M29150 AAA59154 M54894 AAC41704 S56892 AAD13886 X04403 CAA27991 X04430 CAA28026 X04602 CAA28268 XM_005249745 XP_005249802 XM_011515390 XP_011513692 XM_011515391 XP_011513693 NM_000600 NP_000591
Function Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
Subcellular Location Secreted.
Top Pathways Non-alcoholic fatty liver disease (NAFLD), Legionellosis, TNF signaling pathway, Herpes simplex infection, PI3K-Akt signaling pathway

IL-6 (D3K2N) Rabbit mAb - 12153 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3K2N
Western blot analysis of 1 ng recombinant Human Interleukin-6 (hIL-6) #8904 using IL-6 (D3K2N) Rabbit mAb.

IL-6 (H-183) - sc-7920 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IL-6 (H-183): sc-7920. Western blot analysis of human recombinant IL-6.

IL-6 (C12-1-hIL-6) - sc-32296 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-6 (C12-1-hIL-6): sc-32296. Western blot analysis of human recombinant IL-6 fusion protein.

IL-6 (E-4) - sc-28343 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-6 (E-4): sc-28343. Western blot analysis of human recombinant IL-6.

IL-6 (AH65) - sc-53865 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-6 (AH65): sc-53865. Western blot analysis of human recombinant IL-6 fusion protein.

IL-6 (E-15) - sc-323975 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IL-6 (1) - sc-130326 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-6 (1): sc-130326. Western blot analysis of IL-6 expression in non-transfected: sc-117752 (A) and human IL-6 transfected: sc-176119 (B) 293T whole cell lysates.

IL-6 (6D9A1) - sc-65989 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-6 (6D9A1): sc-65989. Western blot analysis of human recombinant IL-6 protein.

IL-6 (Y-15) - sc-323976 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IL-6 (B-F6) - sc-65327 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
IL-6 (B-F6): sc-65327. Western blot analysis of IL-6 expression in non-transfected: sc-117752 (A) and human IL-6 transfected: sc-113126 (B) 293T whole cell lysates.

Active rat IL6 full length protein - ab200272 from Abcam

Prices $206.00
Sizes 2 µg

Anti-IL6 antibody - ab6672 from Abcam

Host Rabbit
Clonality Polyclonal
ab6672 staining IL6 (red)  in Mouse mesenchimal SC cells by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with formaldehyde, permeabilized with 0.5% Tween-20 and blocked with 3% BSA for 1 hour at room temperature. Samples were incubated with primary antibody (1/500 in 3% BSA) for 1 hour. An Alexa Fluor® 555-conjugated Donkey anti-rabbit IgG polyclonal (1:500) was used as the secondary antibody. Blue (DAPI) - nuclei.See Abreview

Anti-IL6 antibody - ab9324 from Abcam

Prices $390.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
ab9324  staining IL6 in human cervical squamous cell carcinoma tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Tissue underwent heat mediated antigen retrieval in sodium citrate buffer (pH 6.0). The primary antibody was used at 0.125 ug/ml and incubated with sample at 4°C overnight. A HRP-labeled polymer detection system was used with a DAB chromogen.

Anti-IL6 antibody - ab154367 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL6 antibody (ab154367) at 1/1000 dilutionLane 1 : A549 whole cell lysateLane 2 : HeLa whole cell lysateLane 3 : HepG2 whole cell lysateLane 4 : HCT116 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-IL6 antibody - ab117341 from Abcam

Prices $378.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
ELISA showing ab117341 at 0.1µg/ml using recombinant Human IL6 protein followed by Goat anti-IgY-HRP.

Anti-IL6 antibody - ab17506 from Abcam

Host Goat
Clonality Polyclonal

Anti-IL6 antibody - ab66231 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
All lanes : Anti-IL6 antibody (ab66231) at 1 µg/mlLane 1 : IL6 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysate. Lysates/proteins at 50 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-IL6 antibody - ab93356 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL6 antibody (ab93356) at 1 µg/mlLane 1 : Lung (Human) Tissue LysateLane 2 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lane 3 : Human Plasma Total Protein LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IL6 antibody - ab7746 from Abcam

Prices $370.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-IL6 antibody - ab43142 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-IL6 antibody (ab43142) at 1/1000 dilutionLane 1 : Total protein extract from E.coli with ~50ng to 100ng of a negative control fusion protein with an irrelevant antigenLane 2 : Total protein extract from E.coli with ~50ng to 500ng of the antigen fusion proteinSecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase conjugated at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IL6 antibody - ab14038 from Abcam

Prices $370.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-IL6 antibody - ab157758 from Abcam

Host Sheep
Clonality Polyclonal

Anti-IL6 antibody - ab193799 from Abcam

Prices $370.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal

Anti-IL6 antibody [33A12] - ab123239 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 33A12
Human PBMCs were left unstimulated (A) or stimulated (B) with 1 ug/mL LPS in the presence of a protein transport inhibitor for 5 hours. Cells were stained with an anti-CD14 antibody (x axis) on the surface and an intracellular stain for anti-IL-6 clone 33A12 (y axis).

Anti-IL6 antibody [33A12] (Biotin) - ab123236 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 33A12
Human PBMCs were left unstimulated (A) or stimulated (B) with 1 ug/mL LPS in the presence of a protein transport inhibitor for 5 hours. Cells were stained with an anti-CD14 antibody (x axis) on the surface and an intracellular stain for anti-IL-6 clone 33A12 (y axis).
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