| Gene Symbol | SPCC132.01c |
|---|---|
| Entrez Gene | 2538747 |
| Alt Symbol | - |
| Species | S. pombe |
| Gene Type | protein-coding |
| Description | nuclear export mediator factor NEMF |
| Other Description | - |
| Swissprots | O94551 Q9USN8 |
| Accessions | CAA22870 Q9USN8 NM_001023135 NP_588145 |
| Function | Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mtr1/rqc2 is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Mtr1/rqc2 is important for the stable association of rkr1/ltn1 to the complex. Mtr1/rqc2 recruits alanine- and threonine-charged tRNA to the A site and directs the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal Ala and Thr extensions (CAT tails). CAT tails induce a heat shock response. {ECO:0000250|UniProtKB:Q12532}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:24928430}. |