| Gene Symbol |
SPCC132.01c
|
| Entrez Gene |
2538747
|
| Alt Symbol |
-
|
| Species |
S. pombe
|
| Gene Type |
protein-coding
|
| Description |
nuclear export mediator factor NEMF
|
| Other Description |
-
|
| Swissprots |
O94551 Q9USN8
|
| Accessions |
CAA22870 Q9USN8 NM_001023135 NP_588145
|
| Function |
Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mtr1/rqc2 is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Mtr1/rqc2 is important for the stable association of rkr1/ltn1 to the complex. Mtr1/rqc2 recruits alanine- and threonine-charged tRNA to the A site and directs the elongation of stalled nascent chains independently of mRNA or 40S subunits, leading to non-templated C-terminal Ala and Thr extensions (CAT tails). CAT tails induce a heat shock response. {ECO:0000250|UniProtKB:Q12532}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16823372, ECO:0000269|PubMed:24928430}.
|