| Gene Symbol | EIF3C |
|---|---|
| Entrez Gene | 8663 |
| Alt Symbol | EIF3CL, EIF3S8, eIF3-p110 |
| Species | Human |
| Gene Type | protein-coding |
| Description | eukaryotic translation initiation factor 3, subunit C |
| Other Description | cell migration-inducing protein 17|eIF3 p110|eukaryotic translation initiation factor 3 subunit 8|eukaryotic translation initiation factor 3 subunit C|eukaryotic translation initiation factor 3, subunit 8 (110kD)|eukaryotic translation initiation factor 3, subunit 8, 110kDa |
| Swissprots | Q9BW98 H3BRV0 A8K7Z0 B4E1D5 Q99613 O00215 B2RXG3 |
| Accessions | AAC27426 AAC27674 AAD03462 EAW50492 EAW50493 EAW50494 EAW50495 EAW50496 Q99613 AA679705 AK000739 BAA91352 AK055366 BAG51506 AK130531 AK292155 BAF84844 AK293264 BAG56795 AK299421 BAG61402 AK301183 BAG62767 AK301233 BAG62805 AK303790 BAG64747 AK304500 BAG65308 AL045958 AY762099 AAX07826 BC000533 AAH00533 BC001571 AAH01571 BC071705 AAH71705 BC107692 AAI07693 BC157842 AAI57843 BC157849 AAI57850 BE780094 BF665714 BM757468 BT007335 AAP35999 BX648075 CA420261 CN410678 DC341554 DQ891632 ABM82558 DQ894822 ABM85748 NM_001037808 NP_001032897 NM_001199142 NP_001186071 NM_001267574 NP_001254503 NM_001286478 NP_001273407 NM_003752 NP_003743 |
| Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. |
| Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}. |
| Top Pathways | RNA transport |
eIF3 p110 CRISPR/Cas9 KO Plasmid (h) - sc-417125 from Santa Cruz Biotechnology
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eIF3 p110 HDR Plasmid (h) - sc-417125-HDR from Santa Cruz Biotechnology
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eIF3 p110 Double Nickase Plasmid (h) - sc-417125-NIC from Santa Cruz Biotechnology
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eIF3 p110 Double Nickase Plasmid (h2) - sc-417125-NIC-2 from Santa Cruz Biotechnology
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eIF3 p110 CRISPR Activation Plasmid (h) - sc-417125-ACT from Santa Cruz Biotechnology
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eIF3 p110 CRISPR Activation Plasmid (h2) - sc-417125-ACT-2 from Santa Cruz Biotechnology
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eIF3 p110 Lentiviral Activation Particles (h) - sc-417125-LAC from Santa Cruz Biotechnology
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eIF3 p110 Lentiviral Activation Particles (h2) - sc-417125-LAC-2 from Santa Cruz Biotechnology
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eIF3 p110 siRNA (h) - sc-40545 from Santa Cruz Biotechnology
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eIF3 p110 shRNA Plasmid (h) - sc-40545-SH from Santa Cruz Biotechnology
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eIF3 p110 shRNA (h) Lentiviral Particles - sc-40545-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU148551 from Sigma-Aldrich
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EIF3C siRNA (Human) - CRH5698 from Cohesion Biosciences
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EIF3C RNAi - H00008663-R01 from Novus Biologicals
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EIF3C - MBS8201209 from MyBioSource
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shRNA set against Human EIF3S8(NM_001037808.1) - SHH029423 from Creative biogene
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Human EIF3C siRNA - orb266200 from Biorbyt
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EIF3C shRNA Plasmid (Human) - CHH5698 from Cohesion Biosciences
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EIF3C miRNA 3'UTR clone - MiUTR3H-06379 from Creative biogene
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EIF3C miRNA 3'UTR clone - MiUTR3H-06380 from Creative biogene
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