Gene Symbol | PRTN3 |
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Entrez Gene | 5657 |
Alt Symbol | ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3 |
Species | Human |
Gene Type | protein-coding |
Description | proteinase 3 |
Other Description | C-ANCA antigen|Wegener granulomatosis autoantigen|azurophil granule protein 7|leukocyte proteinase 3|myeloblastin|neutrophil proteinase 4|serine proteinase, neutrophil|wegener autoantigen |
Swissprots | P15637 Q9UQD8 Q6LBN2 Q4VB08 Q4VB09 P18078 P24158 Q6LBM7 Q9UD25 |
Accessions | AAB59364 EAW69590 EAW69591 P24158 BC096183 AAH96183 BC096184 AAH96184 BC096185 AAH96185 BC096186 AAH96186 FN647680 CBI83574 M29142 AAA36342 M75154 AAA59558 X55668 CAA39203 X56132 CAA39597 X56606 CAA39943 XM_011528136 XP_011526438 XM_011546889 XP_011545191 NM_002777 NP_002768 |
Function | Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters. |
PR3 CRISPR/Cas9 KO Plasmid (h) - sc-402550 from Santa Cruz Biotechnology
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PR3 HDR Plasmid (h) - sc-402550-HDR from Santa Cruz Biotechnology
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PR3 Double Nickase Plasmid (h) - sc-402550-NIC from Santa Cruz Biotechnology
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PR3 Double Nickase Plasmid (h2) - sc-402550-NIC-2 from Santa Cruz Biotechnology
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PR3 CRISPR Activation Plasmid (h) - sc-402550-ACT from Santa Cruz Biotechnology
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PR3 CRISPR Activation Plasmid (h2) - sc-402550-ACT-2 from Santa Cruz Biotechnology
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PR3 Lentiviral Activation Particles (h) - sc-402550-LAC from Santa Cruz Biotechnology
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PR3 Lentiviral Activation Particles (h2) - sc-402550-LAC-2 from Santa Cruz Biotechnology
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PR3 siRNA (h) - sc-42968 from Santa Cruz Biotechnology
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PR3 shRNA Plasmid (h) - sc-42968-SH from Santa Cruz Biotechnology
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PR3 shRNA (h) Lentiviral Particles - sc-42968-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU046021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17555 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17555 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11985 from Sigma-Aldrich
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PRTN3 siRNA (Human) - CRH3814 from Cohesion Biosciences
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Proteinase 3/Myeloblastin/PRTN3 RNAi - H00005657-R01 from Novus Biologicals
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shRNA set against Human PRTN3 (NM_002777.3) - SHH384708 from Creative biogene
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shRNA set against Human PRTN3(NM_002777.3) - SHR145236 from Creative biogene
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Human PRTN3 siRNA - orb264316 from Biorbyt
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PRTN3 shRNA Plasmid (Human) - CHH3814 from Cohesion Biosciences
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PRTN3 miRNA 3'UTR clone - MiUTR1H-08344 from Creative biogene
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