SMO

Gene Symbol SMO
Entrez Gene 6608
Alt Symbol FZD11, Gx, SMOH
Species Human
Gene Type protein-coding
Description smoothened, frizzled class receptor
Other Description frizzled family member 11|protein Gx|seven transmembrane helix receptor|smoothened homolog|smoothened, frizzled family receptor|smoothened, seven transmembrane spanning receptor
Swissprots A4D1K5 Q99835
Accessions AAD17202 BAC05807 EAL24102 EAW83715 Q99835 AF071494 AAC24863 AF089720 AF120103 AAF31757 AF130867 AAD28625 AU132302 BC004332 BC009989 AAH09989 DQ896647 ABM87646 U84401 AAB41788 XM_011516522 XP_011514824 NM_005631 NP_005622
Function G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. {ECO:0000269|PubMed:19592253}.
Subcellular Location Membrane {ECO:0000269|PubMed:22072986}; Multi-pass membrane protein {ECO:0000269|PubMed:22072986}. Cell projection, cilium {ECO:0000269|PubMed:22072986}.
Top Pathways Hedgehog signaling pathway, Basal cell carcinoma, Proteoglycans in cancer

Smo (E-5) - sc-166685 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Smo (E-5): sc-166685. Western blot analysis of Smo expression in K-562 whole cell lysate.

Smo (N-19) - sc-6366 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Smo (N-19): sc-6366. Western blot analysis of Smo expression in mouse embryo tissue extract.

Smo (H-300) - sc-13943 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Smoothened antibody - ab113438 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab113438 at 10 &microg/ml staining Smoothened in Human liver by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Anti-Smoothened antibody - ab58574 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Smoothened antibody (ab58574) at 0.3 µg/ml + Human Bone Marrow lysate at 35 µg

Anti-Smoothened antibody - ab72130 from Abcam

Prices $400.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Smoothened antibody (ab72130) at 0.1 µg/mlLane 1 : Human heart lysate Lane 2 : Human heart lysate with immunising peptide

Anti-SMO / Smoothened Antibody (aa774-786) - LS-C55488 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SMO / Smoothened Antibody (aa555-566) - LS-C55489 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SMO / Smoothened Antibody (Internal) - LS-C209987 from LifeSpan Bioscience

Prices $295.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal

Anti-SMO / Smoothened Antibody (aa539-567, AP) - LS-C217634 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMO / Smoothened Antibody (aa539-567, APC) - LS-C217635 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMO / Smoothened Antibody (aa539-567, Biotin) - LS-C217636 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMO / Smoothened Antibody (aa58-107) - LS-C200709 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HepG2 cells using SMO antibody.

Anti-SMO / Smoothened Antibody (aa539-567, FITC) - LS-C217637 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMO / Smoothened Antibody (aa539-567, Azide-free, HRP) - LS-C217638 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMO / Smoothened Antibody (aa539-567, PE) - LS-C217640 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMO / Smoothened Antibody (aa538-567) - LS-C325210 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SMO / Smoothened Antibody (Val107) - LS-C177498 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Smo (V107) pAb in extracts from HUVEC cells.

Anti-SMO / Smoothened Antibody (aa539-567) - LS-C161317 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
SMO Antibody western blot of HepG2 cell line lysates (35 ug/lane). The SMO antibody detected the SMO protein (arrow).

Anti-SMO / Smoothened Antibody - LS-C140596 from LifeSpan Bioscience

Prices $460.00
Sizes 10 blot
Host Rabbit
Clonality Polyclonal
Western blot of SMO antibody (LS-C140596P) on human brain lysate. Lysate loaded at 15 ug/lane. Antibody used at 10 ug/ml (1) and 5 ug/ml (2) dilution. Secondary antibody, mouse anti-rabbit-HRP, used at 1:150K dilution.

Anti-SMO / Smoothened Antibody (N-Terminal) IHC-plus™ - LS-A2666 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Kidney: Formalin-Fixed Paraffin-Embedded (FFPE)

Anti-SMO / Smoothened Antibody (clone 3E5) IHC-plus™ - LS-B6379 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3E5
Anti-SMO antibody IHC of human placenta, cytotrophoblast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6379 concentration 5 ug/ml.

Anti-SMO / Smoothened Antibody (clone 3D10) IHC-plus™ - LS-B6399 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3D10
Anti-SMO antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6399 concentration 5 ug/ml.

Anti-SMO / Smoothened Antibody (aa68-117) IHC-plus™ - LS-B4911 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SMO antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4911 concentration 10 ug/ml.

Anti-SMO / Smoothened Antibody (aa190-240) - LS-C47301 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of SMOH in formalin-fixed paraffin-embedded human brain tissue using an isotype control (top) and LS-C47301 (bottom) at 10 ug/ml.
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