| Gene Symbol | SMO |
|---|---|
| Entrez Gene | 6608 |
| Alt Symbol | FZD11, Gx, SMOH |
| Species | Human |
| Gene Type | protein-coding |
| Description | smoothened, frizzled class receptor |
| Other Description | frizzled family member 11|protein Gx|seven transmembrane helix receptor|smoothened homolog|smoothened, frizzled family receptor|smoothened, seven transmembrane spanning receptor |
| Swissprots | A4D1K5 Q99835 |
| Accessions | AAD17202 BAC05807 EAL24102 EAW83715 Q99835 AF071494 AAC24863 AF089720 AF120103 AAF31757 AF130867 AAD28625 AU132302 BC004332 BC009989 AAH09989 DQ896647 ABM87646 U84401 AAB41788 XM_011516522 XP_011514824 NM_005631 NP_005622 |
| Function | G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. {ECO:0000269|PubMed:19592253}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:22072986}; Multi-pass membrane protein {ECO:0000269|PubMed:22072986}. Cell projection, cilium {ECO:0000269|PubMed:22072986}. |
| Top Pathways | Hedgehog signaling pathway, Basal cell carcinoma, Proteoglycans in cancer |