| Gene Symbol |
Ciita
|
| Entrez Gene |
12265
|
| Alt Symbol |
C2ta, EG669998, Gm9475, Mhc2ta
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
class II transactivator
|
| Other Description |
MHC class II transactivator
|
| Swissprots |
O78036 O78109 Q9TPP1 P79621 Q31115 O46787
|
| Accessions |
AAB92364 AAB92365 EDK97316 EDK97317 EDK97318 EDK97319 P79621 AF042158 AAC34366 AF042159 AAC34367 AF100709 AAF06838 AF100710 AAF06839 AI182240 AK040723 BAC30683 AK138822 BAE23789 AK143956 BAE25629 AK153609 BAE32115 AK155184 BAE33100 AK155311 BAE33182 AK163054 BAE37173 BC107330 AAI07331 BC107331 AAI07332 BC140358 AAI40359 BC148699 AAI48700 BE850370 U46562 AAB05004 U60653 AAB48859 XM_006521724 XP_006521787 XM_006521725 XP_006521788 XM_006521726 XP_006521789 XM_006521728 XP_006521791 XM_011245810 XP_011244112 NM_001243760 NP_001230689 NM_001243761 NP_001230690 NM_001302618 NP_001289547 NM_001302619 NP_001289548 NM_007575 NP_031601
|
| Function |
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription, the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: phosphorylates the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (By similarity). {
|
| Subcellular Location |
Nucleus. Nucleus, PML body {ECO:0000250}. Note=Recruited to PML body by PML. {ECO:0000250}.
|
| Tissue Specificity |
Isoform 1 is expressed at very high levels in dendritic cells, at very low levels in spleen and thymus and is not detected in other tissues. Isoform 2 is detected at high levels in spleen and tonsil as well as in a number of B-lymphocyte cell lines, and at very low levels in dendritic cells. {ECO:0000269|PubMed:9184229}.
|
| Top Pathways |
Primary immunodeficiency, Toxoplasmosis, Influenza A, Tuberculosis, Antigen processing and presentation
|