| Gene Symbol |
ZDHHC7
|
| Entrez Gene |
55625
|
| Alt Symbol |
DHHC7, SERZ-B, SERZ1, ZNF370
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger, DHHC-type containing 7
|
| Other Description |
DHHC-7|Sertoli cell gene with zinc finger domain-β|palmitoyltransferase ZDHHC7|zinc finger DHHC domain-containing protein 7|zinc finger protein 370|zinc finger, DHHC domain containing 7
|
| Swissprots |
Q9NVD8 Q8WV42 D3DUM1 Q9NXF8
|
| Accessions |
EAW95463 EAW95464 EAW95465 Q9NXF8 AK000286 BAA91055 AK001654 BAA91814 AK023428 AK130081 AK225768 AW235073 BC017702 AAH17702 BC018772 AAH18772 CN427219 DA507340 DQ891968 ABM82894 DQ895157 ABM86083 XM_011523221 XP_011521523 XM_011523222 XP_011521524 XR_429724 NM_001145548 NP_001139020 NM_017740 NP_060210
|
| Function |
Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95. May palmitoylate GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3) and thereby regulate their synaptic clustering and/or cell surface stability (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptors. {ECO:0000250, ECO:0000269|PubMed:22031296}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000269|PubMed:22031296}.
|