| Gene Symbol | KLC1 |
|---|---|
| Entrez Gene | 3831 |
| Alt Symbol | KLC, KNS2, KNS2A |
| Species | Human |
| Gene Type | protein-coding |
| Description | kinesin light chain 1 |
| Other Description | kinesin 2 60/70kDa|medulloblastoma antigen MU-MB-2.50 |
| Swissprots | Q07866 Q86V78 Q7RTM2 Q86V76 Q86TF5 Q7RTM3 Q86V75 Q86V74 Q86V79 F8VTM4 Q7RTQ6 A6NF62 Q7RTQ3 Q7RTP9 Q96H62 Q7RTQ5 Q7RTM5 Q86SF5 Q86V77 |
| Accessions | AAF72543 CAA49349 EAW81832 EAW81833 EAW81834 EAW81835 Q07866 AB451299 BAG70113 AB451431 BAG70245 AF527736 AAP85635 AK054874 AK294508 BAG57724 AL133587 AY180163 AAO62548 AY180164 AAO62549 AY180165 AAO62550 AY180166 AAO62551 AY180167 AAO62552 AY180168 AAO62553 AY180169 AAO62554 AY180170 AAO62555 AY244715 AAO64641 BC008881 AAH08881 BK000678 DAA01262 BK000679 DAA01263 BK000680 DAA01264 BK000681 DAA01265 BK000682 DAA01266 BK000683 DAA01267 BK000684 DAA01268 BK001163 DAA01289 BK001164 DAA01290 BK001165 DAA01291 BK001166 DAA01292 BK001167 DAA01293 BK001168 DAA01294 BK001169 DAA01295 BK001170 DAA01296 BK001171 DAA01297 BK001172 DAA01298 BM988840 BP274336 BP396130 BQ002171 CA433051 CB050619 DA501532 DQ893256 ABM84182 DQ896585 ABM87584 HG506679 HG506680 L04733 AAA16576 NM_001130107 NP_001123579 NM_005552 NP_005543 NM_182923 NP_891553 |
| Function | Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. |
| Subcellular Location | Cell projection, growth cone {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:14970196}. |
| Tissue Specificity | Found in a variety of tissues. Mostly abundant in brain and spine. {ECO:0000269|PubMed:14970196}. |
| Top Pathways | Salmonella infection |
KLC1 CRISPR/Cas9 KO Plasmid (h) - sc-401881 from Santa Cruz Biotechnology
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KLC1 HDR Plasmid (h) - sc-401881-HDR from Santa Cruz Biotechnology
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KLC1 Double Nickase Plasmid (h) - sc-401881-NIC from Santa Cruz Biotechnology
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KLC1 Double Nickase Plasmid (h2) - sc-401881-NIC-2 from Santa Cruz Biotechnology
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KLC1 CRISPR Activation Plasmid (h) - sc-401881-ACT from Santa Cruz Biotechnology
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KLC1 CRISPR Activation Plasmid (h2) - sc-401881-ACT-2 from Santa Cruz Biotechnology
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KLC1 Lentiviral Activation Particles (h) - sc-401881-LAC from Santa Cruz Biotechnology
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KLC1 Lentiviral Activation Particles (h2) - sc-401881-LAC-2 from Santa Cruz Biotechnology
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KLC1 siRNA (h) - sc-43880 from Santa Cruz Biotechnology
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KLC1 shRNA Plasmid (h) - sc-43880-SH from Santa Cruz Biotechnology
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KLC1 shRNA (h) Lentiviral Particles - sc-43880-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN11239 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11239 from Sigma-Aldrich
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KLC1 siRNA (Human) - CRH2594 from Cohesion Biosciences
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shRNA set against Human KLC1 (NM_182923.3) - SHH325655 from Creative biogene
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shRNA set against Human KLC1(NM_182923.3) - SHL199386 from Creative biogene
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shRNA set against Human KLC1(NM_005552.4) - SHL199422 from Creative biogene
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KLC1 shRNA Plasmid (Human) - CHH2594 from Cohesion Biosciences
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KLC1 miRNA 3'UTR clone - MiUTR1H-05343 from Creative biogene
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KLC1 miRNA 3'UTR clone - MiUTR1H-05344 from Creative biogene
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KLC1 miRNA 3'UTR clone - MiUTR3H-03080 from Creative biogene
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