| Gene Symbol | DCTN1 |
|---|---|
| Entrez Gene | 1639 |
| Alt Symbol | DAP-150, DP-150, P135 |
| Species | Human |
| Gene Type | protein-coding |
| Description | dynactin 1 |
| Other Description | 150 kDa dynein-associated polypeptide|dynactin 1 (p150, glued homolog, Drosophila)|dynactin subunit 1 |
| Swissprots | E9PGE1 O95296 Q9UIU2 G5E9H4 Q9UIU1 E9PFS5 B4DM45 A8MY36 Q9BRM9 Q14203 Q6IQ37 |
| Accessions | AAD03694 AAD55811 AAD55812 CCQ43248 EAW99684 EAW99685 EAW99686 EAW99687 Q14203 AB209625 BAD92862 AJ709213 AK055298 AK297286 BAG59757 AK314352 AK315014 BC006163 BC013978 BC071583 AAH71583 BT006758 AAP35404 BX640799 CAE45882 BX647925 CAH10575 BX647972 CAH10572 CA448857 DA111497 DA315227 DA417935 DC309469 EU831597 ACE87197 EU831684 ACE86518 U73799 AAB52575 U90445 AAD00701 X98801 CAA67333 NM_001135040 NP_001128512 NM_001135041 NP_001128513 NM_001190836 NP_001177765 NM_001190837 NP_001177766 NM_004082 NP_004073 NM_023019 NP_075408 NR_033935 |
| Function | Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein- dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17828277}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17828277}. Note=Colocalizes with microtubules. |
| Tissue Specificity | Brain. |
| Top Pathways | Huntington's disease, Vasopressin-regulated water reabsorption |