Gene Symbol |
S100A14
|
Entrez Gene |
57402
|
Alt Symbol |
BCMP84, S100A15
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
S100 calcium binding protein A14
|
Other Description |
S100 calcium-binding protein A14|S114|breast cancer membrane protein 84|protein S100-A14
|
Swissprots |
Q5RHT0 Q9HCY8
|
Accessions |
AAM19206 CAJ42743 Q9HCY8 AY007220 AAG01893 BC005019 AAH05019 BG677973 HQ447959 ADQ32442 XM_005245362 XP_005245419 NM_020672 NP_065723
|
Function |
Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. {ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:22032898, ECO:0000269|PubMed:22451655}.
|
Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11944983}.
|
Tissue Specificity |
Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes. {ECO:0000269|PubMed:11944983}.
|