| Gene Symbol | PLSCR4 |
|---|---|
| Entrez Gene | 57088 |
| Alt Symbol | TRA1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phospholipid scramblase 4 |
| Other Description | Ca(2+)-dependent phospholipid scramblase 4|PL scramblase 4|cell growth inhibiting protein 43 |
| Swissprots | Q658L3 Q2TTR3 Q9NRQ2 Q7Z505 Q6ZR73 A8K2E9 |
| Accessions | CAC88310 CAC88311 EAW78935 EAW78936 EAW78937 EAW78938 Q9NRQ2 AF087887 AAP97186 AF199023 AAF89960 AK128442 BAC87442 AK290214 BAF82903 AK292815 BAF85504 AK312809 BAG35667 AL833760 CAH56232 AW086426 AW665992 AY550971 AAT52217 BC028354 AAH28354 BG538024 BI598345 BP201782 BU160106 BU567842 DA185957 DA444235 DQ890607 ABM92224 EU176540 ABW03341 XM_005247654 XP_005247711 XM_005247655 XP_005247712 XM_011513031 XP_011511333 NM_001128304 NP_001121776 NM_001128305 NP_001121777 NM_001128306 NP_001121778 NM_001177304 NP_001170775 NM_020353 NP_065086 |
| Function | May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. |
| Subcellular Location | Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, uterus, small intestine and colon. Not detected in peripheral blood lymphocytes. |