| Gene Symbol |
Lfng
|
| Entrez Gene |
16848
|
| Alt Symbol |
AW061165
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
|
| Other Description |
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase|beta-1,3-N-acetylglucosaminyltransferase lunatic fringe|lunatic fringe
|
| Swissprots |
Q8K3F1 Q9DC10 Q3U659 O09010
|
| Accessions |
AAM74075 AAM93541 EDL19116 O09010 AF015768 AAB71668 AI116033 AK004642 AK153283 BAE31866 AW061165 BC115680 AAI15681 BC138600 AAI38601 BC138601 AAI38602 BQ571136 U94351 AAC53262 NM_008494 NP_032520
|
| Function |
Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules inhibiting Jagged mediated Notch signaling. Essential mediator of somite segmentation and patterning. During somite boundary formation, it restricts Notch activity in the presomitic mesoderm to a boundary-formig territory in the posterior half of the prospective somite. In this region, Notch function activates a set of genes that are involved in boundary formation and in anterior-posterior somite identity. Ectopically expressed in the thymus, Lfgn inhibits Notch signaling which results in inhibition of T-cell commitment and promotes B- cell development in lymphoid progenitors. May play a role in boundary formation of the enamel knot.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Detected at 12.5 dpc in all tissues examined with the highest level observed in adult brain and spleen. Detected in the dental epithelium.
|
| Top Pathways |
Other types of O-glycan biosynthesis, Notch signaling pathway
|
