| Gene Symbol | Dao |
|---|---|
| Entrez Gene | 114027 |
| Alt Symbol | Dao1 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | D-amino-acid oxidase |
| Other Description | D-amino acid oxidase 1|DAAO|DAMOX |
| Swissprots | O35078 |
| Accessions | EDM13954 EDM13955 EDM13956 EDM13957 O35078 AB003400 BAA22840 BC088395 AAH88395 NM_053626 NP_446078 |
| Function | Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids. |
| Subcellular Location | Peroxisome. |
| Top Pathways | Glycine, serine and threonine metabolism, Peroxisome, Arginine and proline metabolism, D-Arginine and D-ornithine metabolism |