Gene Symbol | MBD4 |
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Entrez Gene | 8930 |
Alt Symbol | MED1 |
Species | Human |
Gene Type | protein-coding |
Description | methyl-CpG binding domain protein 4 |
Other Description | 3,N(4)-ethenocytosine glycosylase|G/5-fluorouracil mismatch glycosylase with biphasic kinetics|G/T mismatch glycosylase|G/U mismatch glycosylase|methyl-CpG-binding domain protein 4|methyl-CpG-binding endonuclease 1|methyl-CpG-binding protein MBD4|mismatch-specific DNA N-glycosylase|putative methyl-CpG binding protein |
Swissprots | Q96F09 Q2MD36 D3DNC3 O95243 D3DNC4 B4DZN2 E9PEE4 Q7Z4T3 |
Accessions | AAD50374 AAM00008 EAW79251 EAW79252 EAW79253 EAW79254 EAW79255 O95243 AF072250 AAC68879 AF114784 AAD22195 AF532602 AAP97338 AK303013 BAG64144 AK312878 AM180876 CAJ55826 BC011752 AAH11752 BC034463 BP370521 BY997577 CD678412 CR450305 CAG29301 DB568237 JF432222 ADZ15439 XM_011513267 XP_011511569 XM_011513268 XP_011511570 NM_001276270 NP_001263199 NM_001276271 NP_001263200 NM_001276272 NP_001263201 NM_001276273 NP_001263202 NM_003925 NP_003916 |
Function | Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. {ECO:0000269|PubMed:10097147, ECO:0000269|PubMed:10930409}. |
Subcellular Location | Nucleus. |
Top Pathways | Base excision repair |
Human MBD4 full length protein - ab185595 from Abcam
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Human MBD4 protein fragment - ab126003 from Abcam
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Recombinant Human MBD4 Protein - H00008930-Q01 from Novus Biologicals
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MBD4-AntibodyCenter-Blocking-peptide - BP19391c from Abgent, a WuXi AppTec company
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MBD4 Blocking Peptide - 33R-10609 from Fitzgerald
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MBD4 - H00008930-P02 from Acris Antibodies
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MBD4 - H00008930-Q01-10 from Acris Antibodies
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MBD4 - H00008930-Q01-25 from Acris Antibodies
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MBD4 fusion protein - ag1822 from Proteintech Group
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Recombinant Human Methyl-CpG-binding domain protein 4(MBD4) - CSB-YP013535HU CSB-EP013535HU CSB-BP013535HU CSB-MP013535HU from Cusabio
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MBD4 Blocking Peptide - 3056BP-50 from Biovision
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MBD4 (human) - pro90024 from Covalab
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MBD4, Peptide - MBS843978 from MyBioSource
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MBD4 Antibody - SH-A13504 from Novatein Biosciences
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MBD4 antibody ( pAb ) , 100 ug - HM-AB1720 from Novatein Biosciences
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MBD4-Antibody-C-term-Blocking-Peptide - BP1039c from Abgent, a WuXi AppTec company
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MBD4-Antibody-Center-Blocking-Peptide - BP1039b from Abgent, a WuXi AppTec company
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MBD4-Antibody-Blocking-Peptide - BP1039a from Abgent, a WuXi AppTec company
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MBD4 Peptide, Human - M34GP09276H from Creative Peptides
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MED1 Peptide, Human - M34GP09352H from Creative Peptides
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Methyl-CpG-binding domain protein 4 (MBD4), Recombinant Protein - MBS1009986 from MyBioSource
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Recombinant Human MBD4 Protein, His-tagged - MBD4-333H from Creative Biomart
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