| Gene Symbol | ATP5F1 |
|---|---|
| Entrez Gene | 515 |
| Alt Symbol | PIG47 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 |
| Other Description | ATP synthase B chain, mitochondrial|ATP synthase F(0) complex subunit B1, mitochondrial|ATP synthase proton-transporting mitochondrial F(0) complex subunit B1|ATP synthase subunit b, mitochondrial|ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1|ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b|ATPase subunit b|H+-ATP synthase subunit b|cell proliferation-inducing protein 47 |
| Swissprots | P24539 Q9BRU8 Q9BQ68 |
| Accessions | EAW56495 EAW56496 P24539 AI754631 AK223018 BAD96738 AK291077 BAF83766 AK308266 AK311287 AK313541 BAG36318 AW385236 AW778751 AY871272 AAX11428 BC005366 AAH05366 BC005960 AAH05960 BC016350 AAH16350 BF237506 D28383 BAA05749 X60221 CAA42782 NM_001688 NP_001679 |
| Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. |
| Subcellular Location | Mitochondrion. Mitochondrion inner membrane. |
| Top Pathways | Alzheimer's disease, Huntington's disease, Oxidative phosphorylation |