| Gene Symbol |
ATP5F1
|
| Entrez Gene |
515
|
| Alt Symbol |
PIG47
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
|
| Other Description |
ATP synthase B chain, mitochondrial|ATP synthase F(0) complex subunit B1, mitochondrial|ATP synthase proton-transporting mitochondrial F(0) complex subunit B1|ATP synthase subunit b, mitochondrial|ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1|ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b|ATPase subunit b|H+-ATP synthase subunit b|cell proliferation-inducing protein 47
|
| Swissprots |
P24539 Q9BRU8 Q9BQ68
|
| Accessions |
EAW56495 EAW56496 P24539 AI754631 AK223018 BAD96738 AK291077 BAF83766 AK308266 AK311287 AK313541 BAG36318 AW385236 AW778751 AY871272 AAX11428 BC005366 AAH05366 BC005960 AAH05960 BC016350 AAH16350 BF237506 D28383 BAA05749 X60221 CAA42782 NM_001688 NP_001679
|
| Function |
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
|
| Subcellular Location |
Mitochondrion. Mitochondrion inner membrane.
|
| Top Pathways |
Alzheimer's disease, Huntington's disease, Oxidative phosphorylation
|