| Gene Symbol | PPP2R5B |
|---|---|
| Entrez Gene | 5526 |
| Alt Symbol | B56B, PR61B |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein phosphatase 2, regulatory subunit B', beta |
| Other Description | PP2A B subunit isoform B'-beta|PP2A B subunit isoform B56-beta|PP2A B subunit isoform PR61-beta|PP2A B subunit isoform R5-beta|protein phosphatase 2, regulatory subunit B', beta isoform|serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, beta isoform|serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform |
| Swissprots | Q13853 Q15173 |
| Accessions | EAW74324 EAW74325 Q15173 AK092730 BC045619 AAH45619 BE883575 BM665417 EU446998 ABZ92527 L42374 AAC37602 XM_006718607 XP_006718670 XM_011545132 XP_011543434 XM_011545133 XP_011543435 XM_011545134 XP_011543436 NM_006244 NP_006235 |
| Function | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the 'Thr-308' and 'Ser-373' residues. {ECO:0000269|PubMed:21329884}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:8703017}. |
| Tissue Specificity | Highest expression in brain. |
| Top Pathways | Oocyte meiosis, mRNA surveillance pathway, Dopaminergic synapse, PI3K-Akt signaling pathway, Adrenergic signaling in cardiomyocytes |