Gene Symbol | BEST4 |
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Entrez Gene | 266675 |
Alt Symbol | VMD2L2 |
Species | Human |
Gene Type | protein-coding |
Description | bestrophin 4 |
Other Description | bestrophin-4|vitelliform macular dystrophy 2-like 2|vitelliform macular dystrophy 2-like protein 2 |
Swissprots | Q5JR93 Q8NFU0 |
Accessions | EAX07022 Q8NFU0 AF440757 AAM76996 AY515707 AAR99657 BC101823 AAI01824 BM142321 XM_005270748 XP_005270805 XM_011541240 XP_011539542 XM_011541241 XP_011539543 XM_011541242 XP_011539544 XM_011541243 XP_011539545 XM_011541244 XP_011539546 XR_946606 NM_153274 NP_695006 |
Function | Forms calcium-sensitive chloride channels. Permeable to bicarbonate. {ECO:0000269|PubMed:12907679, ECO:0000269|PubMed:18400985}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Predominantly found in colon and the weakly in fetal brain, spinal cord, retina, lung, trachea, testis and placenta. {ECO:0000269|PubMed:12032738}. |
Bestrophin-4 CRISPR/Cas9 KO Plasmid (h) - sc-415273 from Santa Cruz Biotechnology
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Bestrophin-4 HDR Plasmid (h) - sc-415273-HDR from Santa Cruz Biotechnology
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Bestrophin-4 Double Nickase Plasmid (h) - sc-415273-NIC from Santa Cruz Biotechnology
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Bestrophin-4 Double Nickase Plasmid (h2) - sc-415273-NIC-2 from Santa Cruz Biotechnology
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Bestrophin-4 CRISPR Activation Plasmid (h) - sc-415273-ACT from Santa Cruz Biotechnology
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Bestrophin-4 CRISPR Activation Plasmid (h2) - sc-415273-ACT-2 from Santa Cruz Biotechnology
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Bestrophin-4 Lentiviral Activation Particles (h) - sc-415273-LAC from Santa Cruz Biotechnology
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Bestrophin-4 Lentiviral Activation Particles (h2) - sc-415273-LAC-2 from Santa Cruz Biotechnology
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Bestrophin-4 siRNA (h) - sc-72643 from Santa Cruz Biotechnology
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Bestrophin-4 shRNA Plasmid (h) - sc-72643-SH from Santa Cruz Biotechnology
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Bestrophin-4 shRNA (h) Lentiviral Particles - sc-72643-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN3951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3951 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06694 from Sigma-Aldrich
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BEST4 siRNA (Human) - CRJ6830 from Cohesion Biosciences
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Bestrophin 4 RNAi - H00266675-R01 from Novus Biologicals
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BEST4 - MBS8223590 from MyBioSource
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shRNA set against Human BEST4 (NM_153274.2) - SHH246402 from Creative biogene
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BEST4 shRNA Plasmid (Human) - CHJ6830 from Cohesion Biosciences
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BEST4 miRNA 3'UTR clone - MiUTR1H-00878 from Creative biogene
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