Gene Symbol | TRDN |
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Entrez Gene | 10345 |
Alt Symbol | CPVT5, TDN, TRISK |
Species | Human |
Gene Type | protein-coding |
Description | triadin |
Other Description | - |
Swissprots | F5H2W7 A5D6W5 Q13061 Q6NSB8 |
Accessions | EAW48157 Q13061 AA401295 AI371054 AI375093 AJ489257 CAD33526 AK291867 BAF84556 AK307619 BC012590 BC029393 AAH29393 BC054863 BC057222 AAH57222 BC070290 AAH70290 BC139910 AAI39911 BC167789 AAI67789 BE646014 BM678702 CR749591 CAH18390 JN900469 AEW10557 U18985 AAA75315 XM_011535382 XP_011533684 NM_001251987 NP_001238916 NM_001256020 NP_001242949 NM_001256021 NP_001242950 NM_001256022 NP_001242951 NM_006073 NP_006064 |
Function | Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation- contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000250|UniProtKB:E9Q9K5, ECO:0000269|PubMed:22422768}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:22422768}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:22422768, ECO:0000269|PubMed:24325401}; Single-pass type II membrane protein {ECO:0000269|PubMed:22422768, ECO:0000269|PubMed:24325401}. |
Triadin CRISPR/Cas9 KO Plasmid (h) - sc-407126 from Santa Cruz Biotechnology
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Triadin HDR Plasmid (h) - sc-407126-HDR from Santa Cruz Biotechnology
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Triadin Double Nickase Plasmid (h) - sc-407126-NIC from Santa Cruz Biotechnology
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Triadin Double Nickase Plasmid (h2) - sc-407126-NIC-2 from Santa Cruz Biotechnology
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Triadin CRISPR Activation Plasmid (h) - sc-407126-ACT from Santa Cruz Biotechnology
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Triadin CRISPR Activation Plasmid (h2) - sc-407126-ACT-2 from Santa Cruz Biotechnology
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Triadin Lentiviral Activation Particles (h) - sc-407126-LAC from Santa Cruz Biotechnology
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Triadin Lentiviral Activation Particles (h2) - sc-407126-LAC-2 from Santa Cruz Biotechnology
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Triadin siRNA (h) - sc-44413 from Santa Cruz Biotechnology
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Triadin shRNA Plasmid (h) - sc-44413-SH from Santa Cruz Biotechnology
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Triadin shRNA (h) Lentiviral Particles - sc-44413-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU123171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21935 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21935 from Sigma-Aldrich
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TRDN siRNA (Human) - CRH7012 from Cohesion Biosciences
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TRDN - MBS8219865 from MyBioSource
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shRNA set against Human TRDN (NM_006073.3) - SHH434116 from Creative biogene
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TRDN shRNA Plasmid (Human) - CHH7012 from Cohesion Biosciences
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