Gene Symbol |
CCL28
|
Entrez Gene |
56477
|
Alt Symbol |
CCK1, MEC, SCYA28
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
chemokine (C-C motif) ligand 28
|
Other Description |
C-C motif chemokine 28|CC chemokine CCL28|chemokine (C-C motif) ligand 28 splice variant chi|mucosae-associated epithelial chemokine|small inducible cytokine A28|small inducible cytokine subfamily A (Cys-Cys), member 28|small-inducible cytokine A28
|
Swissprots |
D7RIE7 Q9NRJ3
|
Accessions |
ABK41944 CAG29882 CAO79483 EAW56057 EAW56058 EAW56059 EAW56060 Q9NRJ3 AF110384 AAG43193 AF220210 AAF87205 AF266504 AAG16691 AK307307 AK312120 BAG35056 BC062668 AAH62668 BC069532 AAH69532 BX486632 CD671712 HM067700 ADH95184 HQ448455 ADQ32935 XR_241706 XR_427660 XR_925633 NM_001301873 NP_001288802 NM_001301874 NP_001288803 NM_001301875 NP_001288804 NM_148672 NP_683513 NM_019846
|
Function |
Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
|
Subcellular Location |
Secreted.
|
Tissue Specificity |
Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.
|
Top Pathways |
Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, Chemokine signaling pathway
|