| Gene Symbol | CHST10 |
|---|---|
| Entrez Gene | 9486 |
| Alt Symbol | HNK-1ST, HNK1ST |
| Species | Human |
| Gene Type | protein-coding |
| Description | carbohydrate sulfotransferase 10 |
| Other Description | HNK-1 sulfotransferase|huHNK-1ST |
| Swissprots | O43529 Q53T18 |
| Accessions | AAX93044 CAJ75915 CBY88424 EAX01841 EAX01842 EAX01843 EAX01844 O43529 AF003827 AF033827 AAC04707 AF070594 AAC28651 AK297267 BAH12534 AK313241 BAG36052 AU124707 BC010441 AAH10441 BU849869 DA522916 DA732392 DQ891064 ABM81990 DQ894245 ABM85171 XM_011512207 XP_011510509 XM_011512208 XP_011510510 XM_011512209 XP_011510511 XM_011512210 XP_011510512 XM_011512211 XP_011510513 XM_011512212 XP_011510514 NM_004854 NP_004845 |
| Function | Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis. {ECO:0000269|PubMed:9478973}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | In fetal tissues, it is predominantly expressed in brain, and weakly expressed in lung, kidney and liver. In adult, it is highly expressed in brain, testis, ovary, expressed at intermediate level in heart, pancreas, skeletal muscle, spleen and thymus, and weakly expressed in other tissues. In brain, it is expressed at higher level in the frontal lobe. {ECO:0000269|PubMed:9478973}. |
| Top Pathways | Other types of O-glycan biosynthesis |