| Gene Symbol | ARRB1 |
|---|---|
| Entrez Gene | 100009235 |
| Alt Symbol | - |
| Species | Rabbit |
| Gene Type | protein-coding |
| Description | arrestin, beta 1 |
| Other Description | beta-arrestin-1 |
| Swissprots | Q95223 |
| Accessions | Q95223 U75838 AAC48753 XM_008263909 XP_008262131 |
| Function | Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G- protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}. Membrane, clathrin- coated pit {ECO:0000305}. Cell projection, pseudopodium {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). {ECO:0000250}. |
| Top Pathways | MAPK signaling pathway, Endocytosis, Chemokine signaling pathway, Phototransduction, Morphine addiction |
Recombinant Rabbit Beta-arrestin-1(ARRB1) - CSB-YP822051RB CSB-EP822051RB CSB-BP822051RB CSB-MP822051RB from Cusabio
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Beta-arrestin-1 (ARRB1), Recombinant Protein - MBS1285505 from MyBioSource
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