MAPK11

Gene Symbol MAPK11
Entrez Gene 5600
Alt Symbol P38B, P38BETA2, PRKM11, SAPK2, SAPK2B, p38-2, p38Beta
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase 11
Other Description MAP kinase 11|MAP kinase p38 beta|mitogen-activated protein kinase p38 beta|mitogen-activated protein kinase p38-2|stress-activated protein kinase-2|stress-activated protein kinase-2b
Swissprots O15472 B0LPG1 O00284 Q15759 L7RT27 A8K730 Q2XNF2 E7ETQ1 B7Z630
Accessions ABB72677 ABY87540 AGC09598 EAW73524 EAW73525 EAW73526 Q15759 AF001008 AAC51250 AF001174 AAC51373 AF031135 AAC12714 AK291845 BAF84534 AK299745 BAH13116 AK308969 AK309046 BC027933 AAH27933 BM857051 BX361670 BX444192 CR456514 CAG30400 CU013114 CAK54545 CU013402 CAK54844 DQ891728 ABM82654 DQ894905 ABM85831 U53442 AAB05036 U92268 AAB66313 Y14440 CAA74792 XM_011530706 XP_011529008 NM_002751 NP_002742 NR_110887
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MAPK14. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid indu
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
Top Pathways VEGF signaling pathway, Inflammatory mediator regulation of TRP channels, Sphingolipid signaling pathway, Retrograde endocannabinoid signaling, Proteoglycans in cancer

p38β MAPK (C28C2) Rabbit mAb - 2339 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C28C2
Western blot analysis of purified recombinant full-length p38 MAPK GST-fusion proteins, using p38β MAPK (C28C2) Rabbit mAb (upper), or a p38 MAPK pan antibody (lower).

p38β (4H6H6) - sc-101427 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p38β (4H6H6): sc-101427. Western blot analysis of p38β expression in non-transfected: sc-117752 (A) and human p38β transfected: sc-114080 (B) 293T whole cell lysates.

p38β (BB10) - sc-33689 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p38β (BB10): sc-33689. Western blot analysis of human recombinant p38β.

p38β (C-16) - sc-6176 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p38β (C-16): sc-6176. Western blot analysis of control COS cells (A) and COS cells transfected with a p38β expression vector (B).

p38β (E-20) - sc-6187 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p38β (E-20): sc-6187. Western blot analysis of p38β-transfected COS cells.

p38β (N-14) - sc-15918 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p38β (N-14): sc-15918. Western blot analysis of p38β expression in non-transfected (A) and p38β transfected COS (B) whole cell lysates.

Anti-MAPK11 antibody - ab37993 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MAPK11 antibody (ab37993) + mouse brain tissue lysateSecondaryHRP-conjugated anti-rabbit IgG

Anti-MAPK11 antibody - ab80116 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MAPK11 antibody - ab167349 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-MAPK11 antibody (ab167349) at 1 µg/mlLane 1 : MAPK11 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.

Anti-MAPK11 antibody - ab57450 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57450 MAPK11 antibody at 1ug/ml.

Anti-MAPK11 antibody [1C2] - ab117949 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C2
All lanes : Anti-MAPK11 antibody [1C2] (ab117949) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY MAPK11 cDNALysates/proteins at 5 µg per lane.

Anti-MAPK11 antibody [4H6H6] - ab63581 from Abcam

Host Mouse
Clonality Monoclonal
Clone 4H6H6
All lanes : Anti-MAPK11 antibody [4H6H6] (ab63581) at 1/500 dilutionLane 1 : Immunising protein (truncated recombinant fragment)Lane 2 : CHO-K1 cell lysate transfected with full length MAPK11 pcDNA 3.1

Anti-MAPK11 antibody [E13-Q] - C-terminal - ab183208 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone E13-Q
Immunofluorescent analysis of HEK293 cells labeling MAPK11 with ab183208 at 1/500 dilution.

Anti-MAPK11 antibody [EPR6526(2)] - ab137066 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6526(2)
All lanes : Anti-MAPK11 antibody [EPR6526(2)] (ab137066) at 1/1000 dilutionLane 1 : Human cerebellum tissue lysateLane 2 : Fetal brain tissue lysate Lysates/proteins at 10 µg per lane.

Anti-MAPK11 antibody [P12-E], prediluted (FITC) - ab183472 from Abcam

Prices $370.00
Sizes 50 tests
Host Rabbit
Clonality Monoclonal
Clone P12-E
Flow cytometric analysis of HEK293 cells (fixed and permeabilized) labeling MAPK11 with ab183472 using 10μl/106 cells (blue) compared with an isotype control (black).

Anti-MAPK11 antibody - Aminoterminal end - ab71518 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MAPK11 antibody - Aminoterminal end (ab71518) at 1/100 dilutionLane 1 : Mouse heart lysateLane 2 : Mouse brain lysateLysates/proteins at 12.5 µg per lane.

Anti-MAPK11 antibody - C-terminal - ab135662 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MAPK11 antibody - C-terminal (ab135662) at 1/100 dilution + Mouse heart tissue lysate at 35 µg

Anti-MAPK11 antibody - Carboxyterminal end - ab37937 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MAPK11 antibody - Carboxyterminal end (ab37937) at 1/100 dilution + Human placenta lysateObserved band size : 42 kDa (why is the actual band size different from the predicted?)

Anti-MAPK11 antibody - N-terminal - ab117243 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MAPK11 antibody - N-terminal (ab117243) at 1/100 dilution + NIH3T3 cell line lysate at 35 µg

Anti-MAPK11 antibody - N-terminal - ab157559 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MAPK11 antibody - N-terminal (ab157559) at 1 µg/ml + Rat Pancreas lysate at 10 µg

Anti-MAPK11 / SAPK2 / p38 Beta Antibody (aa1-30, Biotin) - LS-C262607 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPK11 / SAPK2 / p38 Beta Antibody (aa1-30, APC) - LS-C262605 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPK11 / SAPK2 / p38 Beta Antibody (aa1-30, FITC) - LS-C262608 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPK11 / SAPK2 / p38 Beta Antibody (aa1-30, AP) - LS-C262606 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPK11 / SAPK2 / p38 Beta Antibody (aa1-30, Azide-free, HRP) - LS-C262609 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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