Gene Symbol | Itpr1 |
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Entrez Gene | 25262 |
Alt Symbol | I145TR, IP3R1, InsP3R, InsP3R1, P400 |
Species | Rat |
Gene Type | protein-coding |
Description | inositol 1,4,5-trisphosphate receptor, type 1 |
Other Description | IP-3-R|IP3 receptor|IP3R 1|inositol 1,4,5-triphosphate receptor 1|inositol 1,4,5-triphosphate receptor, type 1|inositol 1,4,5-trisphosphate receptor type 1|type 1 InsP3 receptor|type 1 inositol 1,4,5-trisphosphate receptor |
Swissprots | P29994 Q62869 |
Accessions | EDL91478 P29994 BC091346 AAH91346 BF402715 FQ225812 FQ233552 GQ233032 ACT21453 J05510 AAA41357 M64698 AAA41448 M64699 AAA41447 U38653 AAC53099 U38665 AAB51330 U38812 AAC53100 XM_006236987 XP_006237049 XM_008763167 XP_008761389 XM_008763168 XP_008761390 XM_008763169 XP_008761391 XM_008763170 XP_008761392 XM_008763171 XP_008761393 XM_008763172 XP_008761394 XM_008763173 XP_008761395 XM_008763174 XP_008761396 XM_008763175 XP_008761397 XM_008763176 XP_008761398 XM_008763177 XP_008761399 XM_008763178 XP_008761400 NM_001007235 NP_001007236 NM_001270596 NP_001257525 NM_001270597 NP_001257526 |
Function | Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
Tissue Specificity | Isoform 3 is found in the brain while isoform 7 is found in the fetal brain and peripheral tissues. |
Top Pathways | Long-term potentiation, Long-term depression, GnRH signaling pathway, Glucagon signaling pathway, Thyroid hormone synthesis |
Monoclonal Anti-ITPR1 antibody produced in mouse - SAB5200080 from Sigma-Aldrich
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IP3 Receptor Antibody (OASE00236) - OASE00236 from Aviva Systems Biology
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IP3-Receptor-1-Antibody - AG1355 from Abgent, a WuXi AppTec company
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Anti -ITPR1 (Inositol 1,4,5-trisphosphate Receptor Type 1, IP3 Receptor Isoform 1, IP3R 1,InsP3R1, Type 1 Inositol 1,4,5-trisphosphate Receptor, Type 1 InsP3 Receptor, INSP3R1) - 217471 from USBiological Life Science
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Anti -ITPR1 (Inositol 1,4,5-trisphosphate Receptor Type 1, IP3 Receptor Isoform 1, IP3R 1,InsP3R1, Type 1 Inositol 1,4,5-trisphosphate Receptor, Type 1 InsP3 Receptor, INSP3R1) - 217472 from USBiological Life Science
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Anti -ITPR1 (Inositol 1,4,5-trisphosphate Receptor Type 1, Type 1 Inositol1,4,5-trisphosphate Receptor, IP3R, INSP3R) - 136802 from USBiological Life Science
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IP3 R antibody (ATTO-700) - orb149620 from Biorbyt
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IP3 receptor 1 / ITPR1 antibody - SP5415 from Acris Antibodies
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IP3 - MBS801824 from MyBioSource
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IP3 - MBS800290 from MyBioSource
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IP3 - MBS803110 from MyBioSource
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IP3 - MBS802864 from MyBioSource
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IP3 - MBS802628 from MyBioSource
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IP3 - MBS800846 from MyBioSource
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IP3 - MBS802909 from MyBioSource
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IP3 - MBS803185 from MyBioSource
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IP3 - MBS803726 from MyBioSource
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IP3 - MBS804773 from MyBioSource
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IP3 - MBS804793 from MyBioSource
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IP3 - MBS801466 from MyBioSource
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IP3 - MBS800208 from MyBioSource
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IP3 - MBS802769 from MyBioSource
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IP3 - MBS800469 from MyBioSource
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IP3 - MBS802281 from MyBioSource
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IP3 - MBS802287 from MyBioSource
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