| Gene Symbol | Itpr1 |
|---|---|
| Entrez Gene | 25262 |
| Alt Symbol | I145TR, IP3R1, InsP3R, InsP3R1, P400 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | inositol 1,4,5-trisphosphate receptor, type 1 |
| Other Description | IP-3-R|IP3 receptor|IP3R 1|inositol 1,4,5-triphosphate receptor 1|inositol 1,4,5-triphosphate receptor, type 1|inositol 1,4,5-trisphosphate receptor type 1|type 1 InsP3 receptor|type 1 inositol 1,4,5-trisphosphate receptor |
| Swissprots | P29994 Q62869 |
| Accessions | EDL91478 P29994 BC091346 AAH91346 BF402715 FQ225812 FQ233552 GQ233032 ACT21453 J05510 AAA41357 M64698 AAA41448 M64699 AAA41447 U38653 AAC53099 U38665 AAB51330 U38812 AAC53100 XM_006236987 XP_006237049 XM_008763167 XP_008761389 XM_008763168 XP_008761390 XM_008763169 XP_008761391 XM_008763170 XP_008761392 XM_008763171 XP_008761393 XM_008763172 XP_008761394 XM_008763173 XP_008761395 XM_008763174 XP_008761396 XM_008763175 XP_008761397 XM_008763176 XP_008761398 XM_008763177 XP_008761399 XM_008763178 XP_008761400 NM_001007235 NP_001007236 NM_001270596 NP_001257525 NM_001270597 NP_001257526 |
| Function | Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). {ECO:0000250}. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| Tissue Specificity | Isoform 3 is found in the brain while isoform 7 is found in the fetal brain and peripheral tissues. |
| Top Pathways | Long-term potentiation, Long-term depression, GnRH signaling pathway, Glucagon signaling pathway, Thyroid hormone synthesis |