| Gene Symbol |
Psma7
|
| Entrez Gene |
29674
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
proteasome (prosome, macropain) subunit, alpha type 7
|
| Other Description |
proteasome subunit RC6-1|proteasome subunit alpha type-7
|
| Swissprots |
P48004
|
| Accessions |
EDL88834 P48004 BC127466 AAI27467 CF110813 CF976316 D30804 BAA06463 FQ226344 FQ231713 NM_001008217 NP_001008218
|
| Function |
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions (By similarity). Promotes MAVS degradation and thereby negatively regulates MAVS- mediated innate immune response (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
Proteasome
|