| Gene Symbol |
LTE1
|
| Entrez Gene |
851209
|
| Alt Symbol |
MSI2
|
| Species |
Yeast
|
| Gene Type |
protein-coding
|
| Description |
mitotic regulator LTE1
|
| Other Description |
-
|
| Swissprots |
P07866 D6VPJ4
|
| Accessions |
DAA06964 P07866 NM_001178169 NP_009378
|
| Function |
GDP-GTP exchange factor for TEM1, a Ras-like protein, component of the mitotic exit network (MEN). Activation of TEM1 by LTE1 in the bud ultimately leads to activation of CDC15 followed by the release of CDC14 from the nucleolus, which then inactivates cyclin-dependent kinases (CDKs) activity by several mechanism. Required for TEM1 localization to the bud cortex during mitotic exit. Fine-tunes the timing of the mitotic exit and couples this event with cytokinesis.
|
| Subcellular Location |
Cytoplasm. Bud. Note=The localization to the bud requires interaction with KEL1, as well as the presence of septins, CDC42, CLA4 and RAS2.
|
| Top Pathways |
Cell cycle - yeast
|