OBSCN

Gene Symbol OBSCN
Entrez Gene 84033
Alt Symbol ARHGEF30, UNC89
Species Human
Gene Type protein-coding
Description obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Other Description obscurin|obscurin, myosin light chain kinase|obscurin-MLCK
Swissprots Q8NHN4 Q8NHN7 Q8NHN3 Q5VSU2 Q8NHN5 Q8NHN2 Q8NHN0 Q86YC7 Q9HCD3 Q5T7G8 Q2A664 Q96AA2 Q8NHN9 Q5VST9 Q8NHN1 Q8NHN8 Q9HCL6 Q8NHN6 Q5T7G9
Accessions CAC85745 CAC85746 CAC85747 CAC85749 CAC85750 CAC85751 CAC85752 CAC85753 CAC85754 CAC85755 EAW69866 EAW69867 Q5VST9 AB046776 BAB13382 AB046859 BAB13465 AJ002535 CAC44768 AK024186 AK097489 AL832357 AL833724 CAH56259 AM231061 CAJ76912 BC034746 BC043916 BC098118 AAH98118 BC098262 AAH98262 BC098292 AAH98292 BC099731 AAH99731 BC114382 AAI14383 BC114461 AAI14462 BU180714 CN302348 DB163213 DB445363 DQ400343 ABD63255 XM_005273287 XP_005273344 XM_005273288 XP_005273345 XM_005273289 XP_005273346 XM_005273290 XP_005273347 XM_005273291 XP_005273348 XM_005273292 XP_005273349 XM_005273293 XP_005273350 XM_005273294 XP_005273351 XM_005273295 XP_005273352 XM_005273296 XP_005273353 XM_005273297 XP_005273354 XM_005273298 XP_005273355 XM_005273299 XP_005273356 XM_005273300 XP_005273357 XM_005273301 XP_005273358 XM_005273302 XP_005273359 XM_005273304 XP_005273361 XM_005273305 XP_005273362 XM_005273307 XP_005273364 XM_005273309 XP_005273366 XM_005273310 XP_005273367 XM_006711819 XP_006711882 XM_006711820 XP_006711883 XM_006711821 XP_006711884 XM_006711822 XP_006711885 XM_006711823 XP_006711886 XM_006711824 XP_006711887 XM_006711825 XP_006711888 XM_006711826 XP_006711889 XM_006711827 XP_006711890 XM_006711828 XP_006711891 XM_006711829 XP_006711892 XM_011544290 XP_011542592 XM_011544291 XP_011542593 XM_011544292 XP_011542594 XM_011544293 XP_011542595 XM_011544294 XP_011542596 XM_011544295 XP_011542597 XM_011544296 XP_011542598 XM_011544297 XP_011542599 XM_011544298 XP_011542600 XM_011544299 XP_011542601 NM_001098623 NP_001092093 NM_001271223 NP_001258152 NM_052843 NP_443075
Function Involved in myofibrillogenesis. Seems to be involved in assembly of myosin into sarcomeric A bands in striated muscle. Isoform 3 together with ANK1 isoform Mu17/Ank1.5 may provide a molecular link between the sarcoplasmic reticulum and myofibrils. {ECO:0000269|PubMed:11448995, ECO:0000269|PubMed:16205939}.
Subcellular Location Isoform 3: Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=In differentiating skeletal muscle cells, isoform 3 primarily localizes to the sarcomeric M-line and less frequently to the Z- disk. Isoform 3 colocalizes with ANK1 isoform Mu17/ank1.5 at the M-line in differentiated skeletal muscle cells.

Obscurin (N-16) - sc-82675 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Obscurin (H-300) - sc-68849 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Obscurin (T-17) - sc-82677 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-OBSCN antibody - ab121605 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab121605 at 1/250 dilution staining OBSCN in Paraffin-embedded Human urinary bladder tissue by Immunohistochemistry. Note:strong cytoplasmic positivity in urothelial cells.

Anti-OBSCN antibody - ab121652 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab121652, at 1/3500 dilution, staining OBSCN in paraffin-embedded Human skeletal muscle tissue by Immunohistochemistry.

OBSCN Antibody - NBP1-88819 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: OBSCN Antibody [NBP1-88819] - Staining of human urinary bladder shows strong cytoplasmic positivity in urothelial cells.

OBSCN Antibody - NBP1-88818 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: OBSCN Antibody [NBP1-88818] - Staining of human skeletal muscle shows strong cytoplasmic positivity.

OBSCN Antibody - H00084033-A02 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-OBSCN antibody produced in rabbit - HPA019497 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-OBSCN: <B>Cat. No. HPA019497</B>: Immunohistochemical staining of human urinary bladder shows strong cytoplasmic positivity in urothelial cells.

Anti-OBSCN antibody produced in rabbit - HPA021186 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-OBSCN: <B>Cat. No. HPA021186</B>: Immunohistochemical staining of human skeletal muscle shows strong cytoplasmic positivity.

Obscurin antibody - 55281-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using 55281-1-AP( OBSCN Antibody) at dilution of 1:50 (under 10x lens)

Obscurin antibody - H00084033-A02 from Acris Antibodies

Prices $300.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Obscurin antibody - H00084033-M02 from Acris Antibodies

Prices $360.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 5C20

Obscurin antibody - H00084033-M02A from Acris Antibodies

Prices $360.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 5C20

OBSCN antibody - 55281-1-AP from Proteintech Group

Prices $279.00
Sizes con: 59 μg/150μl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using 55281-1-AP( OBSCN Antibody) at dilution of 1:50 (under 10x lens)

Anti-OBSCN (aa 1551-1649) polyclonal antibody - DPAB-DC3455 from Creative Diagnostics

Host Mouse
Clonality Polyclonal

Anti-OBSCN (aa 5215-5318) polyclonal antibody - DPABH-19190 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-OBSCN (aa 4984-5126) polyclonal antibody - DPABH-19630 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-Obscurin Antibody, clone 4A8 - MABT332 from EMD Millipore

Prices $279.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4A8

Anti-Obscurin Antibody - ABT160 from EMD Millipore

Prices $299.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Obscurin (5C20) - sc-517125 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal

Anti-Obscurin Antibody - ABT160 from Sigma-Aldrich

Prices $299.00
Sizes abt160
Clonality Polyclonal
Immunohistochemistry Analysis:<br />Representative lot data.<br />Formalin Fixed Paraffin Embedded (FFPE) human heart tissues (Fig. 1 and 2) were processed using heat-induced epitope retrieval (HIER). Immunostaining was performed using a 1:1,000 dilution of Cat. No. ABT160, Anti-Obscurin. Reactivity was detected using an Anti-Rabbit secondary antibody and HRP-DAB. Positive cytoplasmic staining was observed in myofibrils of human heart tissues

anti-OBSCN antibody - A005956 from Biobool

Host Rabbit
Clonality Polyclonal

OBSCN, Polyclonal Antibody - MBS7602189 from MyBioSource

Prices $320.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

OBSCN Antibody, Biotin conjugated - CSB-PA729422LD01HU from Cusabio

Host Rabbit
Clonality Polyclonal
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