| Gene Symbol |
Map2k7
|
| Entrez Gene |
26400
|
| Alt Symbol |
5930412N11Rik, JNKK 2, Jnkk2, MAPKK 7, MEK 7, Mapkk7, Mek7, Mkk7, Prkmk7, sek2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase 7
|
| Other Description |
JNK kinase 2|JNK-activating kinase 2|MAP kinase kinase 7|MAPK/ERK kinase 7|c-Jun N-terminal kinase kinase 2|dual specificity mitogen-activated protein kinase kinase 7|map2k7|mitogen activated protein kinase kinase 7|protein kinase, mitogen activated, kinase 7
|
| Swissprots |
O70242 Q8CE90 Q9R1Z3 O35871 Q9R1Z5 O70243 Q9R1Z4 O54780 O35406 Q8BSP1 Q9R1Z6 Q9QWG6 O35720 O35872
|
| Accessions |
AAB63448 EDL21977 EDL21978 EDL21979 EDL21980 EDL21981 EDL21982 EDL21983 Q8CE90 AB005654 BAA24383 AF022112 AAC16274 AF022113 AAC16275 AF060943 AAD15819 AF060944 AAD15820 AF060945 AAD15821 AF060946 AAD15822 AF060947 AAD15823 AK031137 BAC27272 AK165184 BAE38066 AK181654 AK181910 AK196139 AK202520 AK206802 AK211581 AK213976 AK214564 AK218534 AK218599 AK219049 BB842920 BC070467 AAH70467 CO044477 U74463 AAC53364 U74464 AAC53365 U93030 AAB63447 NM_001042557 NP_001036022 NM_001164172 NP_001157644 NM_001291777 NP_001278706 NM_001291778 NP_001278707 NM_001291783 NP_001278712 NM_011944 NP_036074
|
| Function |
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pr
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:9891090}. Cytoplasm {ECO:0000269|PubMed:9891090}.
|
| Tissue Specificity |
Expressed at high levels in brain, lung, liver, skeletal muscle, kidney, and testis and at lower levels in the heart and spleen. {ECO:0000269|PubMed:9312105, ECO:0000269|PubMed:9405446, ECO:0000269|PubMed:9535930}.
|
| Top Pathways |
Neurotrophin signaling pathway, TNF signaling pathway, Epstein-Barr virus infection, Influenza A, Osteoclast differentiation
|