| Gene Symbol |
VIM3
|
| Entrez Gene |
833951
|
| Alt Symbol |
MIJ24.3, MIJ24_3, ORTH1, ORTHRUS 1, VARIANT IN METHYLATION 3
|
| Species |
Arabidopsis thaliana
|
| Gene Type |
protein-coding
|
| Description |
E3 ubiquitin-protein ligase ORTHRUS 1
|
| Other Description |
-
|
| Swissprots |
Q67XP0 Q9FKA7
|
| Accessions |
AED94446 BAB08886 Q9FKA7 AK221256 BAD93904 BT010573 AAQ65196 NM_123317 NP_198771
|
| Function |
E3 ubiquitin-protein ligase. Participates in CpG methylation-dependent transcriptional regulation and epigenetic transcriptional silencing. Mediates ubiquitination with the E2 ubiquitin-conjugating enzymes UBC11, UBC8 and UBC8 homologs (e.g. UBC10, UBC11, UBC28 and UBC29) but not with UBC27, UBC30, UBC32, UBC34 and UBC36. Promotes methylation-mediated gene silencing leading, for example, to early flowering. Can bind to CpG, CpNpG, and CpNpN DNA motifs, with a strong preference for methylated forms, and with highest affinity for CpG substrate. {ECO:0000269|PubMed:17239600, ECO:0000269|PubMed:18643997, ECO:0000269|PubMed:18704160}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00358, ECO:0000269|PubMed:18643997, ECO:0000269|PubMed:18704160}. Note=Broadly distributed in the nucleus and enriched in the heterochromatic chromocenters.
|
| Tissue Specificity |
Expressed in inflorescences and leaves. {ECO:0000269|PubMed:18704160}.
|