| Gene Symbol |
Per1
|
| Entrez Gene |
18626
|
| Alt Symbol |
Per, m-rigui, mPer1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
period circadian clock 1
|
| Other Description |
circadian clock protein PERIOD 1|circadian pacemaker protein Rigui|period circadian protein homolog 1|period homolog 1
|
| Swissprots |
B1ASX0 O35973
|
| Accessions |
AAF87329 BAA94086 EDL10478 EDL10479 O35973 AA051328 AB002108 BAA22634 AF022992 AAC53355 AK081813 BAC38339 AK148202 BAE28412 AK154900 BAE32911 AK172958 BAD32236 AK182563 BC039768 AAH39768 BC091645 AAH91645 XM_006532480 XP_006532543 XM_006532481 XP_006532544 NM_001159367 NP_001152839 NM_011065 NP_035195
|
| Function |
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2.
|
| Tissue Specificity |
In brain, highest expression is observed in the SCN. Highly expressed in the pyramidal cell layer of the piriform cortex, the periventricular part of the caudate-putamen, many thalamic nuclei, and the granular layer of the cerebellar cortex. Weaker expression is detected in most area of the brain, including cortical and non cortical structures. Expression but no oscillations occurs in the glomerular and mitral cell layers of the olfactory bulb, the internal granular layer of the cerebellum, the cornu ammonis and dentate gyrus of the hyppocampus, the cerebral and piriform cortices. Expressed in the renal cortex (at protein level). Also found in heart, brain, bladder, lumbar spinal cord, spleen, lung, liver, skeletal muscle and testis. {ECO:0000269|PubMed:10521578, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:24154698, ECO:0000269|PubMed:24603368, ECO:0000269|PubMed:24610784, ECO:0000269|PubMed:9333243, ECO:0000269|PubMed:9427249}.
|
| Top Pathways |
Circadian rhythm, Herpes simplex infection, Circadian entrainment
|