| Gene Symbol |
THBS1
|
| Entrez Gene |
7057
|
| Alt Symbol |
THBS, THBS-1, TSP, TSP-1, TSP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thrombospondin 1
|
| Other Description |
thrombospondin-1|thrombospondin-1p180
|
| Swissprots |
A8K6H4 P07996 Q59E99 Q15667 B9EGH6 B4E3J7
|
| Accessions |
AAA21127 AAA61178 EAW92379 EAW92380 EAW92381 P07996 AB209912 BAD93149 AI147670 AI168683 AI290070 AK291639 BAF84328 AK293230 BAG56769 AK304754 BAG65509 AK309613 AK310820 AU117102 AU279999 BC015134 BC028145 AAH28145 BC136469 AAI36470 BC136470 AAI36471 BG115371 BG251169 BM512145 BM784452 BU676185 CA411820 LN607833 CEF49520 M14326 AAA61237 M25631 AAA36741 M99425 AAB59366 X04665 CAA28370 X14787 CAA32889 XM_011521970 XP_011520272 XM_011521971 XP_011520273 XR_931897 NM_003246 NP_003237
|
| Function |
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250}.
|
| Top Pathways |
Proteoglycans in cancer, p53 signaling pathway, Rap1 signaling pathway, MicroRNAs in cancer, PI3K-Akt signaling pathway
|
