RPS3

Gene Symbol	RPS3
Entrez Gene	6188
Alt Symbol	S3
Species	Human
Gene Type	protein-coding
Description	ribosomal protein S3
Other Description	40S ribosomal protein S3|IMR-90 ribosomal protein S3
Swissprots	Q498B5 Q8NI95 J3KN86 B2R7N5 P23396
Accessions	AAA18095 AAF82383 AAV40835 BAB79476 EAW74963 P23396 AA976344 AB062288 BAB93471 AK129794 AK130960 AK223048 BAD96768 AK313051 BAG35882 AW134501 BC003137 AAH03137 BC003577 AAH03577 BC013196 AAH13196 BC013231 BC029981 BC034149 AAH34149 BC071669 BC071917 AAH71917 BC100284 AAI00285 BC150501 AAI50502 BE797417 BM831460 BM928330 BQ645330 CB241053 D28344 BAA05710 DQ892888 ABM83814 DQ896136 ABM87135 DW448503 S42658 AAB19349 U14990 AAB60336 U14991 AAB60337 U14992 AAB60338 X55715 CAA39248 NM_001005 NP_000996 NM_001256802 NP_001243731 NM_001260506 NP_001247435 NM_001260507 NP_001247436
Function	Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16314389, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:17560175, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:21871177}. Nucleus {ECO:0000269|PubMed:17560175, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:19460357, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:21871177}. Nucleus, nucleolus {ECO:0000269|PubMed:16314389, ECO:0000269|PubMed:19460357}. Mitochondrion inner membrane {ECO:0000269|PubMed:23911537}; Peripheral membrane protein {ECO:0000269|PubMed:23911537}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23131551}. Note=In normal cells, located mainly in the cytoplasm with small amounts in the nucleus but translocates to the nucleus in cells undergoing apoptosis (By similarity). Nuclear translocation is induced by DNA damaging agents such as hydrogen peroxide (PubMed:17560175). Accumulates in the mitochondrion in response to increased ROS levels (PubMed:23911537). Localizes to the spindle during mitosis (
Top Pathways	Ribosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RPS3 full length protein - ab113158 from Abcam Category Protein Source E. coli Species Human

Human RPS3 full length protein - ab108585 from Abcam Category Protein Source E. coli Species Human

Human RPS3 full length protein - ab108589 from Abcam Category Protein Source E. coli Species Human

Human RPS3 peptide - ab86941 from Abcam Category Peptide

RPS3 Recombinant Protein - H00006188-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 10 ug 25 ug Species Human

RPS3 Partial Recombinant Protein - H00006188-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human RPS3 Protein - NBP1-72495 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

RPS3-Antibody-C-term-Blocking-peptide - BP12605b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human RPS3 protein - orb169219 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

RPS3 peptide - orb217889 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Zebrafish, Drosophila, Cat

RPS3 protein (His tag) - 80R-2007 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

RPS3 Blocking Peptide - abx063220 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Dog, Pig, Zebrafish

RPS3 (1-243, His-tag) - AR50079PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

RPS3 (1-243, His-tag) - AR50079PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

RPS3 - H00006188-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RPS3 - H00006188-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RPS3 - H00006188-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RPS3 - H00006188-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RPS3, 1-243aa, Human, His tag, E.coli - 01-2193-3 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

RPS3 fusion protein - Ag7515 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RPS3 fusion protein - ag0624 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RPS3 fusion protein - ag3918 from Proteintech Group Category Protein Source E. coli-derived, Species Human

RPS3 fusion protein - ag7346 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Ribosomal Protein S3 - BP002430-PRO-954 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

RPS3, 1-243aa, Recombinant Protein - GWB-P0784D from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

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