DISC1

Gene Symbol	DISC1
Entrez Gene	27185
Alt Symbol	C1orf136, SCZD9
Species	Human
Gene Type	protein-coding
Description	disrupted in schizophrenia 1
Other Description	disrupted in schizophrenia 1 protein
Swissprots	Q8IXJ1 A6NLH2 Q8IXJ0 Q9BX19 C4P0A3 C4P0C1 C4P0B6 C4P0B3 Q5VT44 O75045 Q9NRI4 C4P095 Q9NRI5 Q9NRI3 C4P091 C9J6D0 Q5VT45 C4P0A1
Accessions	AAF73874 AAF73877 EAW69966 EAW69967 Q9NRI5 AB007926 BAA32302 AF222980 AAF73889 AI075754 AJ506177 CAD44631 AJ506178 CAD44628 AK023443 AK025293 AK096457 AL049973 BC038954 BC142622 BC151225 AAI51226 FJ804174 ACR40040 FJ804175 ACR40041 FJ804176 ACR40042 FJ804177 ACR40043 FJ804178 ACR40044 FJ804179 ACR40045 FJ804180 ACR40046 FJ804181 ACR40047 FJ804182 ACR40048 FJ804183 ACR40049 FJ804184 ACR40050 FJ804185 ACR40051 FJ804186 ACR40052 FJ804187 ACR40053 FJ804188 ACR40054 FJ804189 ACR40055 FJ804190 ACR40056 FJ804191 ACR40057 FJ804192 ACR40058 FJ804193 ACR40059 FJ804194 ACR40060 FJ804195 ACR40061 FJ804196 ACR40062 FJ804197 ACR40063 FJ804198 ACR40064 FJ804199 ACR40065 FJ804200 ACR40066 FJ804201 ACR40067 FJ804202 ACR40068 FJ804203 ACR40069 FJ804204 ACR40070 FJ804205 ACR40071 FJ804206 ACR40072 FJ804207 ACR40073 FJ804208 ACR40074 FJ804209 ACR40075 FJ804210 ACR40076 FJ804211 ACR40077 FJ804212 ACR40078 FJ804213 ACR40079 FJ804214 ACR40080 FJ804215 ACR40081 FJ804216 ACR40082 KJ534822 AHW56462 NM_001012957 NP_001012975 NM_001012958 NP_001012976 NM_001012959 NP_001012977 NM_001164537 NP_001158009 NM_001164538 NP_001158010 NM_001164539 NP_001158011 NM_001164540 NP_001158012 NM_001164541 NP_001158013 NM_001164542 NP_001158014 NM_001164544 NP_001158016 NM_001164545 NP_001158017 NM_001164546 NP_001158018 NM_001164547 NP_001158019 NM_001164548 NP_001158020 NM_001164549 NP_001158021 NM_001164550 NP_001158022 NM_001164551 NP_001158023 NM_001164552 NP_001158024 NM_001164553 NP_001158025 NM_001164554 NP_001158026 NM_001164555 NP_001158027 NM_001164556 NP_001158028 NM_018662 NP_061132 NM_001039383
Function	Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. {ECO:0000269|PubMed:18955030, ECO:0000269|PubMed:19303846, ECO:0000269|PubMed:19502360}.
Subcellular Location	Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome. {ECO:0000250}.
Tissue Specificity	Ubiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter. {ECO:0000269|PubMed:16510495}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DISC1 peptide (108-120) - ab45846 from Abcam Category Peptide Prices $290.00 Sizes 100 µg Species Human

DISC1 Antibody Blocking Peptide - LS-E3594 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DISC1 Antibody Blocking Peptide - LS-E26144 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DISC1 Antibody Blocking Peptide - LS-E30377 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DISC1 Antibody Blocking Peptide - LS-E30376 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DISC1 Blocking Peptide - NB110-40775PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

DISC1 Peptide - NB110-40773PEP from Novus Biologicals Category Peptide Prices $99.00 Sizes 50 µg

DISC1-Antibody-C-term-Blocking-Peptide - BP14796b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DISC1 blocking peptide - GTX89158-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

DISC1 Blocking Peptide - 33R-1012 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DISC1 Blocking Peptide - 33R-4772 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human DISC1 Protein - abx066352 from Abbexa Category Protein Source E.coli Species Human

DISC1 Peptide - AC21-0974-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DISC1 Control Peptide - AP09977CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

DISC1 Control Peptide - AP30291CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

DISC1 Control Peptide - AP30292CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

DISC1 Peptide - 4293P from ProSci Category Peptide Species Human

DISC1 Peptide - 4295P from ProSci Category Peptide Species Human

DISC1 Peptide - 45-481P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

Recombinant Disrupted In Schizophrenia 1 (DISC1) - RPC265Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Disrupted In Schizophrenia 1 (DISC1) - RPC265Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Disrupted In Schizophrenia 1 (DISC1) - RPC265Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Human Disrupted in schizophrenia 1 protein(DISC1) ,partial - CSB-YP889093HU CSB-EP889093HU CSB-BP889093HU CSB-MP889093HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DISC1 (a.a. 740-753) - DX3025 from ECM Biosciences Category Peptide Prices $55.00 Sizes 50 μg

Disrupted In Schizophrenia 1 (DISC1) - RPU141214 from Biomatik Category Protein Prices $242.00, $484.00, $726.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Human

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