| Gene Symbol |
SLC26A8
|
| Entrez Gene |
116369
|
| Alt Symbol |
SPGF3, TAT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 26 (anion exchanger), member 8
|
| Other Description |
anion transporter/exchanger-8|testis anion transporter 1
|
| Swissprots |
Q96RN1 Q5JVR5 Q96MA0 Q812C7 Q96PK8 Q8TC65
|
| Accessions |
EAX03862 EAX03863 EAX03864 EAX03865 EAX03866 Q96RN1 AF314959 AAL26868 AF331522 AAK95666 AI015633 AK055314 AK057276 BAB71408 AK097410 AK122928 AK125189 BC025408 AAH25408 BG702985 JF432316 ADZ15533 XM_011514294 XP_011512596 XR_926055 NM_001193476 NP_001180405 NM_052961 NP_443193 NM_138718 NP_619732
|
| Function |
Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation. {ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11834742, ECO:0000269|PubMed:22121115}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:17517695}; Multi-pass membrane protein {ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:17517695}. Note=Located at the annulus ring structure within the sperm cell. {ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:17517695}.
|
| Tissue Specificity |
Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in spermatozoa. {ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11834742}.
|