| Gene Symbol |
CAMSAP3
|
| Entrez Gene |
57662
|
| Alt Symbol |
KIAA1543, NEZHA, PPP1R80
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calmodulin regulated spectrin-associated protein family, member 3
|
| Other Description |
calmodulin-regulated spectrin-associated protein 3|protein phosphatase 1, regulatory subunit 80
|
| Swissprots |
Q8NDF1 Q9P1Y5
|
| Accessions |
EAW69025 EAW69026 EAW69027 EAW69028 Q9P1Y5 AB040976 BAA96067 AF289580 AAL55764 AL833927 CAD38783 BC020431 BC035808 BC036935 BC064490 BC128201 AAI28202 BC128202 AAI28203 BU733578 XM_005272491 XP_005272548 XM_006722806 XP_006722869 XM_011528154 XP_011526456 NM_001080429 NP_001073898 NM_020902 NP_065953
|
| Function |
Microtubule minus-end binding protein that acts as a regulator of non-centrosomal microtubule dynamics and organization. Specifically required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites. May regulate the nucleation and the polymerization of microtubules. Indirectly, through the microtubule cytoskeleton, may regulate the organization of cellular organelles including the Golgi and the early endosomes. {ECO:0000269|PubMed:19041755, ECO:0000269|PubMed:23169647}.
|
| Subcellular Location |
Cell junction, adherens junction. Cytoplasm. Cytoplasm, cytoskeleton. Note=Scattered in the cytoplasm, associated with the minus-end of microtubules and also detected at the centrosomes. Localizes along zonula adherens only at mature cell-cell contacts.
|