| Gene Symbol |
NFKBIL1
|
| Entrez Gene |
4795
|
| Alt Symbol |
IKBL, LST1, NFKBIL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
|
| Other Description |
I-kappa-B-like protein|NF-kappa-B inhibitor-like protein 1|ikappaBL|inhibitor of kappa B-like protein
|
| Swissprots |
Q5HYU4 B4DUW1 A6NL91 Q5RJ72 Q9UBX4 Q14625 Q5ST96 Q9UBC1 Q5STV4 Q5STV5
|
| Accessions |
BAB63398 BAC54951 BAE78635 BAF31285 CAA75072 EAX03417 EAX03418 EAX03419 EAX03420 EAX03421 Q9UBC1 AF097419 AAD38108 AF097420 AAD38109 AF097421 AAD38110 AF097422 AAD38111 AF097423 AAD38112 AF097424 AAD38113 AF097425 AAD38114 AF097426 AAD38115 AF097427 AAD38116 AF097428 AAD38117 AF097429 AAD38118 AK291893 BAF84582 AK300818 BAG62473 AK313888 BC105064 AAI05065 BC105068 AAI05069 BC143671 AAI43672 BM044744 DC370256 EU446511 ABZ92040 X77909 CAA54867 NM_001144961 NP_001138433 NM_001144962 NP_001138434 NM_001144963 NP_001138435 NM_005007 NP_004998
|
| Function |
Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. {ECO:0000269|PubMed:20829348}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:20829348}. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus.
|
| Tissue Specificity |
Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.
|