Gene Symbol | IGSF5 |
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Entrez Gene | 150084 |
Alt Symbol | GSF5, JAM4 |
Species | Human |
Gene Type | protein-coding |
Description | immunoglobulin superfamily, member 5 |
Other Description | JAM-4|immunoglobulin superfamily 5 like|immunoglobulin superfamily member 5|junctional adhesion molecule 4 |
Swissprots | Q9NSI5 |
Accessions | CAB90447 CCQ43066 Q9NSI5 AK092516 BAG52565 BC114922 BC156232 AAI56233 BC157006 AAI57007 HG511824 HG511825 HG511826 XM_011529472 XP_011527774 XM_011529473 XP_011527775 NM_001080444 NP_001073913 |
Function | Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia- spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells- Sertoli cells (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. |
Top Pathways | Tight junction, Epithelial cell signaling in Helicobacter pylori infection |
JAM4 CRISPR/Cas9 KO Plasmid (h) - sc-409048 from Santa Cruz Biotechnology
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JAM4 HDR Plasmid (h) - sc-409048-HDR from Santa Cruz Biotechnology
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JAM4 Double Nickase Plasmid (h) - sc-409048-NIC from Santa Cruz Biotechnology
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JAM4 Double Nickase Plasmid (h2) - sc-409048-NIC-2 from Santa Cruz Biotechnology
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JAM4 CRISPR Activation Plasmid (h) - sc-409048-ACT from Santa Cruz Biotechnology
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JAM4 CRISPR Activation Plasmid (h2) - sc-409048-ACT-2 from Santa Cruz Biotechnology
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JAM4 Lentiviral Activation Particles (h) - sc-409048-LAC from Santa Cruz Biotechnology
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JAM4 Lentiviral Activation Particles (h2) - sc-409048-LAC-2 from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU050211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10544 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10544 from Sigma-Aldrich
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IGSF5 siRNA (Human) - CRJ5638 from Cohesion Biosciences
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IGSF5 - MBS8200958 from MyBioSource
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shRNA set against Human Igsf5 (NM_001080444.1) - SHH317873 from Creative biogene
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shRNA set against Human LOC150084(NM_001080444.1) - SHL169320 from Creative biogene
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IGSF5 shRNA Plasmid (Human) - CHJ5638 from Cohesion Biosciences
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IGSF5 miRNA 3'UTR clone - MiUTR1H-05740 from Creative biogene
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